Evidence map›Paper›PMID 39316098›Full record

ArticleMikrochimica acta2024

Sensitive and reliable lab-on-paper biosensor for label-free detection of exosomes by electrochemical impedance spectroscopy.

Sevda Akay Sazaklioglu, Hilal Torul, Uğur Tamer, Hilal Kabadayi Ensarioglu, Hafize Seda Vatansever, Bilal H Gumus, Hüseyin Çelikkan

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sevda Akay SazakliogluFaculty of Pharmacy, Department of Analytical Chemistry, Ankara Medipol University, 06050, Ankara, Turkey.
Hilal TorulFaculty of Pharmacy, Department of Analytical Chemistry, Gazi University, 06330, Ankara, Turkey.
Uğur TamerFaculty of Pharmacy, Department of Analytical Chemistry, Gazi University, 06330, Ankara, Turkey.
Hilal Kabadayi EnsariogluFaculty of Medicine, Department of Histology and Embryology, Manisa Celal Bayar University, 45200, Manisa, Turkey.
Hafize Seda VatanseverFaculty of Medicine, Department of Histology and Embryology, Manisa Celal Bayar University, 45200, Manisa, Turkey.
Bilal H GumusFaculty of Medicine, Department of Urology, Manisa Celal Bayar University, 45200, Manisa, Turkey.
Hüseyin ÇelikkanFaculty of Science, Department of Chemistry, Gazi University, 06560, Ankara, Turkey. celikkan@gazi.edu.tr.

Funding

Gazi Üniversitesi FCD-2021-7119
6 · The paper itself

Abstract

A new, sensitive, and cost-effective lab-on-paper-based immunosensor was designed based on electrochemical impedance spectroscopy (EIS) for the detection of exosomes. EIS was selected as the determination method since there was a surface blockage in electron transfer by binding the exosomes to the transducer. Briefly, the carbon working electrode (WE) on the paper electrode (PE) was modified with gold particles (AuPs@PE) and then conjugated with anti-CD9 (Anti-CD9/AuPs@PE) for the detection of exosomes. Variables involved in the biosensor design were optimized with the univariate mode. The developed method presents the limit of detection of  8.7 × 10

Indexed as

Biosensing TechniquesDielectric SpectroscopyExosomesGoldLimit of DetectionPaperAntibodies, ImmobilizedElectrodesHumansImmunoassayMetal NanoparticlesTetraspanin 29Antibodies, ImmobilizedCD9 protein, humanGoldTetraspanin 29Electrochemical impedance spectroscopyExosomesGold particle modified electrodeLabel-free detectionPaper-based electrode

Identifiers

PMID39316098

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.