Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
42 authors.
Jara Cárcel-MárquezStroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).ORCID 0000-0002-6949-0699
Elena MuiñoStroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).ORCID 0000-0001-5839-7328
Cristina Gallego-FabregaStroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).ORCID 0000-0003-3229-5512
Natalia CullellStroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).ORCID 0000-0001-5118-1014
Miquel LledósStroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).ORCID 0000-0001-8832-789X
Laia Llucià-CarolStroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).ORCID 0000-0002-7732-0665
Jesús M Martín-CamposStroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).ORCID 0000-0003-0414-037X
Tomás SobrinoClinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (T. Sobrino, F.C., J.C.), La Coruña, Spain.ORCID 0000-0002-9760-8690
Francisco CamposClinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (T. Sobrino, F.C., J.C.), La Coruña, Spain.ORCID 0000-0001-8665-1039
José CastilloClinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (T. Sobrino, F.C., J.C.), La Coruña, Spain.ORCID 0000-0002-6685-3001
Marimar FreijoBiocruces-Bizkaia Health Research Institute, Department of Neurology, Bilbao, Spain (M.F.).ORCID 0000-0002-4293-8705
Juan Francisco ArenillasStroke Unit, Department of Neurology, University Hospital of Valladolid, Spain (J.F.A.).ORCID 0000-0001-7464-6101
Victor ObachDepartment of Neurology, Hospital Clínic de Barcelona, IDIBAPS, Spain (V.O.).ORCID 0000-0002-0518-1053
José Álvarez-SabínStroke Unit, Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.A.-S., C.A.M., M.R.).
Carlos A MolinaStroke Unit, Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.A.-S., C.A.M., M.R.).ORCID 0000-0001-6058-6259
Marc RibóStroke Unit, Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.A.-S., C.A.M., M.R.).ORCID 0000-0001-9242-043X
Jordi Jiménez-CondeDepartment of Neurology, IMIM-Hospital del Mar; Neurovascular Research Group, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain (J.J.-C., J.R.).
Jaume RoquerDepartment of Neurology, IMIM-Hospital del Mar; Neurovascular Research Group, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain (J.J.-C., J.R.).ORCID 0000-0001-5992-2606
Lucia Muñoz-NarbonaDepartment of Neurosciences, Hospital Germans Trias I Pujol (L.M.-N., M.M.), Universitat Autònoma de Barcelona, Spain.ORCID 0000-0002-0884-3024
Elena Lopez-CancioDepartament of Neurology, University Hospital Central de Asturias, Spain (E.L.-C.).ORCID 0000-0001-5757-9074
Mònica MillánDepartment of Neurosciences, Hospital Germans Trias I Pujol (L.M.-N., M.M.), Universitat Autònoma de Barcelona, Spain.ORCID 0000-0002-4692-5936
Rosa Diaz-NavarroDepartment of Neurology, Son Espases University Hospital, Illes Balears Health Research Institute, Spain (R.D.-N., C.V.-B.).
Cristòfol Vives-BauzaDepartment of Neurology, Son Espases University Hospital, Illes Balears Health Research Institute, Spain (R.D.-N., C.V.-B.).ORCID 0000-0001-5735-8335
Gemma Serrano-HerasDepartment of Neurology, University Hospital of Albacete, Spain (G.S.-H., T. Segura).ORCID 0000-0001-9368-4832
Tomás SeguraDepartment of Neurology, University Hospital of Albacete, Spain (G.S.-H., T. Segura).ORCID 0000-0003-3625-0987
Laura IbañezDepartment of Psychiatry (L.I., C.C.), Washington University School of Medicine, St. Louis, MO.
Laura HeitschDepartment of Neurology (L.I., L.H., R.D., J.-M.L.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-8712-4123
Pilar DelgadoNeurovascular Research Laboratory, Vall d'Hebron Institute of Research (P.D.), Universitat Autònoma de Barcelona, Spain.ORCID 0000-0002-1628-4488
Rajat DharDepartment of Neurology (L.I., L.H., R.D., J.-M.L.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-5167-5097
Jerzy KrupinskiNeurology Service, Hospital Universitari Mútua Terrassa, Spain (J.K.).
Luis Prats-SánchezStroke Unit (L.P.-S., P.C.-R., M.G., G.E., J.M.-F.), Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID 0000-0002-3192-4631
Pol Camps-RenomStroke Unit (L.P.-S., P.C.-R., M.G., G.E., J.M.-F.), Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID 0000-0001-6587-6271
Marina GuaschStroke Unit (L.P.-S., P.C.-R., M.G., G.E., J.M.-F.), Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID 0000-0001-6024-8348
Garbiñe EzcurraStroke Unit (L.P.-S., P.C.-R., M.G., G.E., J.M.-F.), Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID 0000-0002-9511-3117
Natalia BlayGenomesForLife-GCAT Lab (N.B., R.d.C.), Germans Trias i Pujol Research Institute, Barcelona, Spain.ORCID 0000-0002-7160-8529
Lauro SumoyHigh Content Genomics and Bioinformatics Unit (L.S.), Germans Trias i Pujol Research Institute, Barcelona, Spain.ORCID 0000-0003-0005-4618
Rafael de CidGenomesForLife-GCAT Lab (N.B., R.d.C.), Germans Trias i Pujol Research Institute, Barcelona, Spain.ORCID 0000-0003-3579-6777
Joan MontanerInstitute de Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC/University of Seville and Department of Neurology, Hospital Universitario Virgen Macarena, Spain (J.M.).ORCID 0000-0003-4845-2279
Carlos CruchagaDepartment of Psychiatry (L.I., C.C.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-0276-2899
Jin-Moo LeeDepartment of Neurology (L.I., L.H., R.D., J.-M.L.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-3979-0906
Joan Martí-FàbregasStroke Unit (L.P.-S., P.C.-R., M.G., G.E., J.M.-F.), Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID 0000-0001-9229-8649
Israel Férnandez-CadenasStroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).ORCID 0000-0003-4821-2363
Funding
Genetic Architecture of Cerebral Edema after StrokeR01NS121218 · NINDS · WASHINGTON UNIVERSITY · PI Rajat Raj Dhar · 2022 to 2026
$1.9M
NINDS NIH HHS R01 NS121218
6 · The paper itself
Abstract
backgroundIschemic stroke (IS) represents a significant health burden globally, necessitating a better understanding of its genetic underpinnings to improve prevention and treatment strategies. Despite advances in IS genetics, studies focusing on the Spanish population and sex-stratified analyses are lacking.
methodsA case-control genome-wide association study was conducted with 9081 individuals (3493 IS cases and 5588 healthy controls). IS subtypes using Trial of ORG 10172 in Acute Stroke Treatment criteria were explored in a sex-stratified approach. Replication efforts involved the MEGASTROKE, GIGASTROKE, and the UK Biobank international cohorts. Post-genome-wide association study analysis included: in silico proteomic analysis, gene-based analysis, quantitative trait loci annotation, transcriptome-wide association analysis, and bioinformatic analysis using chromatin accessibility data.
resultsIdentified as associated with IS and its subtypes were 4 significant and independent loci. Replication confirmed 5p15.2 as a new locus associated with small-vessel occlusion stroke, with rs59970332-T as the lead variant (beta [SE], 0.13 [0.02];
conclusionsWe found
Indexed as
Genome-Wide Association StudyStroke, LacunarAgedCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansIschemic StrokeMaleMiddle AgedPolymorphism, Single NucleotideSpaingenome-wide association studygenomicsischemic strokeSpainstroke
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke. · full record | OpenQuestion