Evidence map›Paper›PMID 39315797›Full record

ArticleJournal of bacteriology2024

Phosphorylation of VapB antitoxins affects intermolecular interactions to regulate VapC toxin activity in

Basanti Malakar, Valdir C Barth, Julia Puffal, Nancy A Woychik, Robert N Husson

Abstract read
In one paragraph

Article in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Basanti MalakarDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-3073-2398
Valdir C BarthDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-7410-1598
Julia PuffalDepartment of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.ORCID 0000-0003-3066-5225
Nancy A WoychikDepartment of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.ORCID 0000-0002-3996-2990
Robert N HussonDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-8994-7046

Funding

Genome exploration through toxin-mediated ribosome stallingR01AI154464 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI WOYCHIK, NANCY ANN · 2020 to 2023
$1.5M
Regulation of VapC toxins by Ser/Thr phosphorylation of VapB antitoxins in M. tuberculosisR21AI146539 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI HUSSON, ROBERT N · 2020 to 2021
$487k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI154464HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI146539NIAID NIH HHS R01 AI154464NIAID NIH HHS R21 AI146539
6 · The paper itself

Abstract

Toxin-antitoxin modules are present in many bacterial pathogens. The VapBC family is particularly abundant in members of the

Indexed as

Bacterial ProteinsBacterial ToxinsGene Expression Regulation, BacterialMycobacterium tuberculosisAntitoxinsDNA-Binding ProteinsMembrane GlycoproteinsOperonPhosphorylationPromoter Regions, GeneticProtein BindingAntitoxinsBacterial ProteinsBacterial ToxinsDNA-Binding ProteinsMembrane GlycoproteinsVapB protein, Bacteriabacterial stress responselatencyMycobacterium tuberculosispersistenceprotein phosphorylationtoxin–antitoxinVapBVapC

Identifiers

PMID39315797
PMCPMC11500542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.