Evidence map›Paper›PMID 39315610›Full record

ArticleGenetics2024

Admixture in the fungal pathogen Blastomyces.

Gaston I Jofre, Andrius J Dagilis, Victoria E Sepúlveda, Tayte Anspach, Ashutosh Singh, Anuradha Chowdhary, Daniel R Matute

Abstract read
In one paragraph

Article in Genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gaston I JofreDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8670-5236
Andrius J DagilisDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0003-2013-0825
Victoria E SepúlvedaDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Tayte AnspachDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Ashutosh SinghNational Reference Laboratory for Antimicrobial Resistance in Fungal Pathogens, Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110021, India.ORCID 0000-0002-6807-7130
Anuradha ChowdharyNational Reference Laboratory for Antimicrobial Resistance in Fungal Pathogens, Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110021, India.
Daniel R MatuteDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.

Funding

Tri-Institutional Molecular Mycology and Pathogenesis Training ProgramT32AI052080 · NIAID · DUKE UNIVERSITY · PI ANDREW ALSPAUGH, JOSEPH HEITMAN · 2003 to 2026
$8.7M
The evolution of virulence in the fungal pathogen HistoplasmaR01AI153523 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MATUTE, DANIEL · 2021 to 2025
$3.2M
NIAID NIH HHS R01 AI153523NIAID NIH HHS T32 AI052080
6 · The paper itself

Abstract

Blastomyces is an emerging primary fungal pathogen that affects patients worldwide. The evolutionary processes that have resulted in the current diversity in the genus remain largely unexplored. We used whole genome sequences from 99 Blastomyces isolates, including two sequenced in this study using long-read technologies, to infer the phylogenetic relationships between Blastomyces species. We find that five different methods infer five different phylogenetic trees. Additionally, we find gene tree discordance along the genome with differences in the relative phylogenetic placement of several species of Blastomyces, which we hypothesize is caused by introgression. Our results suggest the urgent need to systematically collect Blastomyces samples around the world and study the evolutionary processes that govern intra- and interspecific variation in these medically important fungi.

Indexed as

hybridizationintrogressionspeciation

Identifiers

PMID39315610
PMCPMC11631411

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.