Evidence map›Paper›PMID 39315463›Full record

ArticleNephrology (Carlton, Vic.)2024

Trends of bone mineral density and bone quality in a paediatric kidney transplant recipient: A case report.

Jun Aoyagi, Takahiro Kanai, Takane Ito, Takashi Saito, Hiroyuki Betsui, Masanori Kurosaki, Tomomi Maru, Marika Ono, Toshihiro Tajima

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology (Carlton, Vic.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun AoyagiDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.ORCID https://orcid.org/0000-0001-6899-6797
Takahiro KanaiDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.ORCID https://orcid.org/0000-0002-9673-6201
Takane ItoDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.
Takashi SaitoDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.
Hiroyuki BetsuiDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.
Masanori KurosakiDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.
Tomomi MaruDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.
Marika OnoDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.
Toshihiro TajimaDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplant (KT) requires long-term glucocorticoid (GC) treatment against acute and/or chronic rejection. Glucocorticoid-induced osteoporosis (GIOP) is one of the major concerns in kidney transplant recipients (KTRs). Therefore, it is essential to accumulate GIOP data from paediatric KTRs to aid in their healthy growth. A serial observational study of bone strength was carried out in an 8-year-old girl with bilateral hypoplastic kidney who underwent ABO-compatible living-donor KT and GC treatment over 2 years. Bone strength was evaluated by bone mineral density (BMD) and serum bone turnover markers (BTMs), including serum alkaline phosphatase (S-ALP), serum tartrate-resistant acid phosphatase 5b (S-TRACP-5b), and serum undercarboxylated osteocalcin (S-ucOC). All the levels of BTMs and BMD from 1 M to 4 M remained lower than the levels at 0 months (0 M: baseline). After gradual reduction of GC dose (4 M-24 M), S-ALP levels increased from baseline and S-TRACP-5b levels remained lower than the baseline level, but BMD recovered to baseline and increased. The S-ucOC levels did not increase from baseline. The patient's height growth velocity SDS was +3.99 for 23 months, and no fracture occurred during this observation period. A consistent, predominantly formative state of bone, which maintained higher S-ALP levels and lower S-TRACP-5b levels compared to baseline, could contribute to increased BMD. In addition, no increase in S-ucOC levels from baseline could be associated with no deterioration of bone strength. This case suggests that measurement of BMD and, S-ALP, TRACP-5b and ucOC could be useful for evaluating the trend on bone strength in a paediatric KTR.

Indexed as

BiomarkersBone DensityGlucocorticoidsKidney TransplantationOsteoporosisTartrate-Resistant Acid PhosphataseAbsorptiometry, PhotonAlkaline PhosphataseBone RemodelingChildFemaleHumansImmunosuppressive AgentsOsteocalcinTime FactorsTreatment OutcomeACP5 protein, humanAlkaline PhosphataseBGLAP protein, humanBiomarkersGlucocorticoidsImmunosuppressive AgentsOsteocalcinTartrate-Resistant Acid Phosphatasebone mineral densitybone turnover markerchildglucocorticoid‐induced osteoporosiskidney transplant

Identifiers

PMID39315463
PMCPMC13547132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.