Evidence map›Paper›PMID 39315450›Full record

ArticleJournal of natural products2024

Computationally-Assisted Discovery and Assignment of a New Class of 6/6/5/5 Fused-Ring Diterpene Acting as Pregnane X Receptor Ligands from

Zhiwei Bian, Xiaoying Liu, Shian Hu, Hongyi Li, Jared S Wood, R Thomas Williamson, Jiabao Liu, Ying Chen, Jin Shi, Carolyn L Cummins and 5 more

Abstract read
In one paragraph

Article in Journal of natural products, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhiwei BianSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.
Xiaoying LiuSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.
Shian HuSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.
Hongyi LiState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, P. R. China.
Jared S WoodDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28403, United States.ORCID 0000-0002-3940-0461
R Thomas WilliamsonDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28403, United States.ORCID 0000-0001-7450-3135
Jiabao LiuDepartment of Chemistry, The Donnelly Centre, University of Toronto, Toronto M5S 3E1, Canada.
Ying ChenDepartment of Biology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada.
Jin ShiDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Carolyn L CumminsDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
Daneel FerreiraDepartment of Biomolecular Sciences, Division of Pharmacognosy, and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, Mississippi 38677, United States.ORCID 0000-0002-9375-7920
Yeun-Mun ChooDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0001-9891-5898
Shengpeng WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, P. R. China.ORCID 0000-0003-3575-9212
Mark T HamannDrug Discovery, Biomedical Sciences and Public Health, Medical University of South Carolina, Charleston, South Carolina 29425, United States.ORCID 0000-0002-3798-4002
Xiaojuan WangSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.ORCID 0000-0001-5559-6997

Funding

Synthesis and Optimization of the Aleutianamine Class of AlkaloidsR01GM145845 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HAMANN, MARK T, TIUS, MARCUS ANTONIUS · 2022 to 2025
$2.4M
Natural Product HCV Drugs from Rare Plant-Microbe InteractionsR01AT007318 · NCCIH · UNIVERSITY OF MISSISSIPPI · PI HAMANN, MARK T · 2012 to 2016
$1.6M
NCCIH NIH HHS R01 AT007318NIGMS NIH HHS R01 GM145845
6 · The paper itself

Abstract

We report here the orchestration of molecular ion networking (MoIN) and a set of computationally assisted structural elucidation approaches in the discovery and assignment of a new class of rearranged 4,5-

Indexed as

DiterpenesIsodonPregnane X ReceptorAbietanesAnimalsHumansLigandsLipopolysaccharidesMiceMolecular StructureReceptors, SteroidAbietanesDiterpenesLigandsLipopolysaccharidesPregnane X ReceptorReceptors, Steroidserra Aserra Bserra C

Identifiers

PMID39315450
PMCPMC12582125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.