Evidence map›Paper›PMID 39315279›Full record

ArticleResearch square2024

Hematological and biochemical profiles, infection and habitat quality in an urban rat population.

Ticiana Carvalho-Pereira, Gabriel G Pedra, Daiana S de Oliveira, Fabio N Souza, Caio G Zeppelini, Luana R N Santos, Ricardo D Couto, Thiago C Bahiense, Eduardo M da Silva, Michael Begon and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ticiana Carvalho-PereiraFederal University of Bahia.
Gabriel G PedraUniversity of Liverpool.
Daiana S de OliveiraInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde.
Fabio N SouzaFederal University of Bahia.
Caio G ZeppeliniFederal University of Bahia.
Luana R N SantosInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde.
Ricardo D CoutoFederal University of Bahia.
Thiago C BahienseFederal University of Bahia.
Eduardo M da SilvaFederal University of Bahia.
Michael BegonUniversity of Liverpool.
Mitermayer Galvão ReisInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde.
Albert I KoYale University.
James E ChildsYale University.
Federico CostaFederal University of Bahia.

Funding

Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
Disease Determinants of Urban LeptospirosisU01AI088752 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG · 2010 to 2014
$3.6M
Natural History of Urban LeptospirosisR01AI052473 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG · 2003 to 2013
$2.8M
Ecoepidemiology of leptospirosis in the urban slums of BrazilR01TW009504 · FIC · YALE UNIVERSITY · PI BEGON, MICHAEL, CHILDS, JAMES EMORY · 2012 to 2016
$2.2M
Rodent Population Dynamics and Leptospirosis Infection in Urban Slum EnviornmentsF31AI114245 · NIAID · YALE UNIVERSITY · PI HACKER, KATHRYN PATRICIA · 2014 to 2015
$55k
FIC NIH HHS R01 TW009504FIC NIH HHS R25 TW009338NIAID NIH HHS F31 AI114245NIAID NIH HHS R01 AI052473NIAID NIH HHS U01 AI088752Wellcome Trust
6 · The paper itself

Abstract

Host condition is key in understanding disease dynamics. In an urban population of Rattus norvegicus, we aimed to assess whether infection of Leptospira interrogans and helminths was associated with patterns of host hematological and hormone-biochemical stress-related conditions. Rat kidney imprints and urine were used to identify and quantify L. interrogans, and feces samples for helminth eggs and corticosterone metabolites. Blood samples were taken for complete blood counts and specific biochemicals in rats' sera. Principal Component Analyses were performed to check whether rats would be grouped according to health profiles. We obtained hematological and hormone-biochemical data from 95 and 61 rats, respectively. Hematological PCA revealed distinct rat groups: typical (T), eosinophil deficient (Eos-D), eosinophil- and monocyte- deficient (EM-D) and monocyte deficient with high immature neutrophils (Mon-D). No association between L. interrogans or helminths and rat health profiles was observed, except with Trichiuridae, which mean intensity was significantly higher when all deficient groups were pooled together compared to the T-group. The poorest condition group was found in areas with fewer rat burrows than the T-group, indicating EM-D had a reduced ability to occupy "good" quality habitats. In natural populations, hematological profiles may reflect host's overall condition, instead of responses to specific infections.

Indexed as

habitat qualityhelminth specieshematological profilehormone-biochemical related stresshost conditioninfectionLeptospira interrogansRattus norvegicus

Identifiers

PMID39315279
PMCPMC11419261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.