Evidence map›Paper›PMID 39315268›Full record

ArticleResearch square2024

Cellular indexing of transcriptomes and epitopes (CITE-Seq) in hidradenitis suppurativa identifies dysregulated cell types in peripheral blood and facilitates diagnosis via machine learning.

Sugandh Kumar, Faye Orcales, Bobby B Shih, Xiaohui Fang, Congcong Yin, Ashley Yates, Peter Dimitrion, Isaac Neuhaus, Chandler Johnson, Indra Adrianto and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sugandh KumarDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7000-4718
Faye OrcalesDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
Bobby B ShihDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
Xiaohui FangDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
Congcong YinCenter for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, USA.ORCID 0000-0003-0865-2823
Ashley YatesDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
Peter DimitrionCenter for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, USA.
Isaac NeuhausDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
Chandler JohnsonDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
Indra AdriantoCenter for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, USA.
Antonia WialaClinic Landstrasse, Department of Dermatology, 1030 Vienna, Austria.
Iltefat HamzaviCenter for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, USA.
Li ZhouCenter for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, USA.
Haley NaikDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
Christian PoschClinic Landstrasse, Department of Dermatology, 1030 Vienna, Austria.
Qing-Sheng MiCenter for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, USA.ORCID 0000-0002-1411-6827
Wilson LiaoDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.

Funding

Using whole-exome sequencing to uncover key genetic variants related to Hidradenitis Suppurativa risk in African American and Hispanic population.R01AR078688 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON, MI, QING-SHENG · 2021 to 2025
$4.1M
Genetic risk of hidradenitis suppurativa in African AmericansR21AR079089 · NIAMS · HENRY FORD HEALTH SYSTEM · PI ADRIANTO, INDRA, MI, QING-SHENG · 2022 to 2023
$520k
NIAMS NIH HHS R01 AR078688NIAMS NIH HHS R21 AR079089
6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by painful nodules, abscesses, and scarring, predominantly affecting intertriginous regions and it is often underdiagnosed. This study aimed to utilize single cell RNA and cell-surface protein sequencing (CITE-Seq) to delineate the immune composition of circulating cells in Hidradenitis suppurativa (HS) peripheral blood compared to healthy controls. CITE-Seq was used to analyze the gene and protein expression profiles of peripheral blood mononuclear cells (PBMCs) from 9 HS and 29 healthy controls. The study identified significant differences cell composition between HS patients and healthy controls, including increased proportions of CD14+ and CD16+ monocytes, cDC2, plasmablasts, and proliferating CD4+ T cells in HS patients. Differential expression analysis revealed upregulation of inflammatory markers such as TNF,

Indexed as

cell-cell interactionCITE-seqdiagnostic testhidradenitis suppurativamachine learningpathway enrichment analysessingle cell

Identifiers

PMID39315268
PMCPMC11419166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.