Evidence map›Paper›PMID 39315260›Full record

ArticleResearch square2024

BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells.

Ashley Toussaint, Manohar Singh, Guoquiang Wang, Monica Driscoll, Vrushank Bhatt, Jean De La Croix Ndong, Sahil Shuaib, Harrison Zoltowski, John Gilleran, Youyi Peng and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ashley ToussaintRutgers State University of New Jersey.
Manohar SinghRutgers State University of New Jersey.
Guoquiang WangRutgers State University of New Jersey.
Monica DriscollRutgers State University of New Jersey.
Vrushank BhattRutgers Cancer Institute of New Jersey.
Jean De La Croix NdongRutgers State University of New Jersey.
Sahil ShuaibRutgers State University of New Jersey.
Harrison ZoltowskiRutgers State University of New Jersey.
John GilleranRutgers State University of New Jersey.
Youyi PengRutgers Cancer Institute of New Jersey.
Anastassiia TsymbalRutgers State University of New Jersey.
Dongxuan JiaRutgers State University of New Jersey.
Jacques RobergeRutgers State University of New Jersey.
Hellen ChiouRutgers State University of New Jersey.
Jessie Yanxiang GuoRutgers Cancer Institute of New Jersey.
Daniel HerranzRutgers Cancer Institute of New Jersey.
John LangenfeldRutgers State University of New Jersey.

Funding

Rutgers Optimizes Innovation (ROI) ProgramU01HL150852 · NHLBI · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI LIBUTTI, STEVEN K., PANETTIERI, REYNOLD ALEXANDER · 2019 to 2022
$4.4M
Targeting BMP type 2 receptor for the treatment of breast cancer.R01CA225830 · NCI · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI LANGENFELD, JOHN · 2018 to 2022
$3.2M
NCI NIH HHS R01 CA225830NHLBI NIH HHS U01 HL150852
6 · The paper itself

Abstract

Background: Bone morphogenetic protein (BMP) signaling cascade is a phylogenetically conserved stem cell regulator that is aberrantly expressed in non-small cell lung cancer (NSLC) and leukemias. BMP signaling negatively regulates mitochondrial bioenergetics in lung cancer cells. The impact of inhibiting BMP signaling on mitochondrial bioenergetics and the effect this has on the survival of NSLC and leukemia cells are not known. Methods: Utilizing the BMP type 2 receptor (BMPR2) JL189, BMPR2 knockout (KO) in cancer cells, and BMP loss of function mutants in Results: BMPR2i increases mtCa

Indexed as

BMP inhibitorcancercell deathfree radicalsmitochondrial calcium

Identifiers

PMID39315260
PMCPMC11419183

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.