Evidence map›Paper›PMID 39315249›Full record

ArticleResearch square2024

Trehalose catalytic shift is an intrinsic factor in Mycobacterium tuberculosis that enhances phenotypic heterogeneity and multidrug resistance.

Hyungjin Eoh, Jae Jin Lee, Daniel Swanson, Sun-Kyung Lee, Stephanie Dihardjo, Gi Yong Lee, Gelle Sree, Emily Maskill, Zachary Taylor, Michael Van Nieuwenhze and 5 more

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Hyungjin EohUniversity of Southern California.ORCID 0000-0001-8774-6400
Jae Jin LeeUniversity of Southern California.ORCID 0000-0001-8317-437X
Daniel SwansonCentral Michigan University.
Sun-Kyung LeeInternal Tuberculosis Research Center.
Stephanie DihardjoUniversity of Southern California.
Gi Yong LeeUniversity of Southern California.
Gelle SreeUniversity of Southern California.
Emily MaskillCentral Michigan University.
Zachary TaylorIndiana University Bloomington.
Michael Van NieuwenhzeBaylor University.
Abhyudai SinghUniversity of Delaware.ORCID 0000-0002-1451-2838
Jong-Seok LeeInternational Tuberculosis Research Center.
Seok-Yong EumInternal Tuberculosis Research Center.
Sang-Nae ChoYonsei University College of Medicine.
Benjamin SwartsCentral Michigan University.

Funding

Interplay of M. tuberculosis trehalose metabolism and its pathogenesis and drug resistanceR01AI168088 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Hyungjin Eoh · 2023 to 2026
$2.6M
Generalized fluctuation test for deciphering phenotypic switching within cell populationsR35GM148351 · NIGMS · UNIVERSITY OF DELAWARE · PI Abhyudai Singh · 2023 to 2026
$1.6M
Metabolic compensation in Mycobacterium tuberculosis for the formation of persistersR21AI139386 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EOH, HYUNGJIN · 2019 to 2020
$454k
NIAID NIH HHS R01 AI168088NIAID NIH HHS R21 AI139386NIGMS NIH HHS R35 GM148351
6 · The paper itself

Abstract

Drug-resistance (DR) in many bacterial pathogens often arises from the repetitive formation of drug-tolerant bacilli, known as persisters. However, it is unclear whether

Identifiers

PMID39315249
PMCPMC11419184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.