Evidence map›Paper›PMID 39315230›Full record

ArticleHeliyon2024

Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement.

Monika Pupíková, Pablo Maceira-Elvira, Sylvain Harquel, Patrik Šimko, Traian Popa, Martin Gajdoš, Martin Lamoš, Umberto Nencha, Kristína Mitterová, Adam Šimo and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04986787 (Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition in Healthy Seniors and Patients With MCI), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04986787 naunknown statusnot on this map

Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition in Healthy Seniors and Patients With MCI

TypeinterventionalSponsorMasaryk UniversityRan2021 to 2023Enrolled160ConditionsMild Cognitive Impairment, Healthy AgingArmstACS, TMS, TIS
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Monika PupíkováApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Pablo Maceira-ElviraNeuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), Chemin des Mines 9, 1202, CH, Geneva, Switzerland.
Sylvain HarquelNeuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), Chemin des Mines 9, 1202, CH, Geneva, Switzerland.
Patrik ŠimkoApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Traian PopaNeuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), Chemin des Mines 9, 1202, CH, Geneva, Switzerland.
Martin GajdošInternational Clinical Research Center, Faculty of Medicine and St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.
Martin LamošInternational Clinical Research Center, Faculty of Medicine and St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.
Umberto NenchaNeuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), Chemin des Mines 9, 1202, CH, Geneva, Switzerland.
Kristína MitterováApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Adam ŠimoFirst Department of Neurology, Faculty of Medicine and St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.
Friedhelm C HummelNeuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), Chemin des Mines 9, 1202, CH, Geneva, Switzerland.
Irena RektorováApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging populations face significant cognitive challenges, particularly in working memory (WM). Transcranial alternating current stimulation (tACS) offer promising avenues for cognitive enhancement, especially when inspired by brain physiology. This study (NCT04986787) explores the effect of multifocal tACS on WM performance in healthy older adults, focusing on fronto-parietal network modulation. Individualized physiology-inspired tACS applied to the fronto-parietal network was investigated in two blinded cross-over experiments. The first experiment involved monofocal/bifocal theta-tACS to the fronto-parietal network, while in the second experiment cross-frequency theta-gamma interactions between these regions were explored. Participants have done online WM tasks under the stimulation conditions. Network connectivity was assessed via rs-fMRI and multichannel electroencephalography. Prefrontal monofocal theta tACS modestly improved WM accuracy over sham (d = 0.30). Fronto-parietal stimulation enhanced WM task processing speed, with the strongest effects for bifocal in-phase theta tACS (d = 0.41). Cross-frequency stimulations modestly boosted processing speed with or without impairing task accuracy depending on the stimulation protocol. This research adds to the understanding of physiology-inspired brain stimulation for cognitive enhancement in older subjects.

Indexed as

CognitionElectric field modellingHealthy agingMultifocalNeuroimagingOrchestrated brain stimulationSystems neurosciencetACSWorking memory

Identifiers

PMID39315230
PMCPMC11417162

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.