Evidence map›Paper›PMID 39315194›Full record

ArticleHeliyon2024

A pilot pharmacokinetic and Metabolite identification study of Erinacine A in a Single landrace pig model.

Ying-Yu Chen, Ting-Wei Lin, I-Chen Li, Lin Tsung, Chun-Hsiang Hou, Chi-Yu Yang, Tsung-Ju Li, Chin-Chu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Yamabushitake Mushroom (International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying-Yu ChenBiotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.
Ting-Wei LinBiotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.
I-Chen LiBiotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.
Lin TsungGLP Animal Laboratory, Agricultural Technology Research Institute, Hsinchu 300, Taiwan.
Chun-Hsiang HouGLP Animal Laboratory, Agricultural Technology Research Institute, Hsinchu 300, Taiwan.
Chi-Yu YangGLP Animal Laboratory, Agricultural Technology Research Institute, Hsinchu 300, Taiwan.
Tsung-Ju LiBiotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.
Chin-Chu ChenBiotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erinacine A has been proven to have the ability to protect nerves and have the benefit of neurohealth. However, the pharmacokinetic and metabolites study of erinacine A in pigs, whose physiology and anatomy are similar to humans, have not been reported. In this study, 5 mg/kg of erinacine A was intravenously administered to the landrace pig. Blood, cerebrospinal fluid, and brain tissue samples were collected and analyzed by HPLC-QQQ/MS and UPLC-QTOF/MS. The results indicated the following pharmacokinetic parameters in plasma samples: with an area under the plasma concentration versus time curve (AUC) were 38.02 ± 0.03 mg∙min/L (AUC

Indexed as

Blood-brain barrierErinacine AErinacine BLandrace pigMetaboliteNerve growth factorPharmacokinetic

Identifiers

PMID39315194
PMCPMC11417322

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.