Evidence map›Paper›PMID 39314962›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Aravind Lathika Rajendrakumar, Konstantin G Arbeev, Olivia Bagley, Matt Duan, Anatoliy I Yashin, Svetlana Ukraintseva, Alzheimer’s Disease Neuroimaging Initiative

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Aravind Lathika RajendrakumarBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, North Carolina, United States of America.ORCID 0000-0002-4286-7265
Konstantin G ArbeevBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, North Carolina, United States of America.ORCID 0000-0002-4195-7832
Olivia BagleyBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, North Carolina, United States of America.
Matt DuanBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, North Carolina, United States of America.
Anatoliy I YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, North Carolina, United States of America.
Svetlana UkraintsevaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, North Carolina, United States of America.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Understanding Alzheimer's Disease in the Context of the AgingR01AG062623 · NIA · DUKE UNIVERSITY · PI OUKRAINTSEVA, SVETLANA V. · 2019 to 2023
$3.6M
Leveraging population-based human data to uncover mechanisms connecting Alzheimer's disease and common infections and facilitate vaccines repurposing for AD preventionR01AG076019 · NIA · DUKE UNIVERSITY · PI OUKRAINTSEVA, SVETLANA V. · 2021 to 2025
$3.1M
NIA NIH HHS R01 AG062623NIA NIH HHS R01 AG076019NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Background: Impaired brain glucose metabolism is a preclinical feature of neurodegenerative diseases such as Alzheimer's disease (AD). Infections may promote AD-related pathology. Therefore, we investigated the interplay between infections and Methods: We analyzed data on 1,509 participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database using multivariate linear regression models. The outcomes were rank-normalized hypometabolic convergence index (HCI), statistical regions of interest (SROI) for AD, and mild cognitive impairment (MCI). Marginal mean estimates for infections, stratified by Results: Prior infections were associated with greater HCI [β=0.15, 95% CI: 0.03, 0.27, p=0.01]. The combined effects of infections and Conclusion: Our findings suggest that infections and

Indexed as

Alzheimer’s DiseaseAPOE4Brain HypometabolismHypometabolic Convergence IndexInfectionsStatistical Regions of Interest

Identifiers

PMID39314962
PMCPMC11419198

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.