Evidence map›Paper›PMID 39314956›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Sleep inertia drives the association of evening chronotype with psychiatric disorders: epidemiological and genetic evidence.

Angus C Burns, Stephanie Zellers, Daniel P Windred, Iyas Daghlas, Nasa Sinnott-Armstrong, Martin Rutter, Christer Hublin, Eleni Friligkou, Renato Polimanti, Andrew J K Phillips and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Angus C BurnsDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston MA.ORCID 0000-0001-6336-5531
Stephanie ZellersInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-8927-3483
Daniel P WindredFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.ORCID 0000-0002-7461-7498
Iyas DaghlasDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Nasa Sinnott-ArmstrongHerbold Computational Biology Program, Public Health Sciences Division, Fred Hutch, Seattle, WA, USA.ORCID 0000-0003-4490-0601
Martin RutterDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, M13 9PL, UK.ORCID 0000-0001-6380-539X
Christer HublinWorking Ability and Working Careers, Finnish Institute of Occupational Health, Helsinki, Finland.
Eleni FriligkouDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT.ORCID 0009-0003-3682-0991
Renato PolimantiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-0745-6046
Andrew J K PhillipsFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Sean W CainFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.ORCID 0000-0002-8385-1550
Jaakko KaprioInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Hanna M OllilaProgram in Medical and Population Genetics, Broad Institute, Cambridge MA.ORCID 0000-0002-5302-6429
Richa SaxenaDivision of Sleep Medicine, Harvard Medical School, Boston MA.ORCID 0000-0003-2233-1065
Jacqueline M LaneDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston MA.ORCID 0000-0001-6101-2855

Funding

Leveraging human genetics to overcome complex diagnostic challenges, evaluation of pan-ancestry polygenic scores to reduce misdiagnosis of narcolepsy and circadian rhythm sleep wake disorders.R01HG012810 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel J Gottlieb · 2023 to 2026
$2.6M
NHGRI NIH HHS R01 HG012810
6 · The paper itself

Abstract

Evening chronotypes (a.k.a. "night-owls") are held to be at greater risk for psychiatric disorders. This is postulated to be due to delayed circadian timing increasing the likelihood of circadian misalignment in an early-oriented society. Circadian misalignment is known to heighten sleep inertia, the difficulty transitioning from sleep to wake characterized by low arousal and cognitive impairment, and evening chronotypes experience greater sleep inertia. Therefore, difficulty awakening may explain the relationship between evening chronotype and psychiatric disorders by acting as a biomarker of circadian misalignment. In analyzing the longitudinal incidence of psychiatric disorders in the UK Biobank (

Identifiers

PMID39314956
PMCPMC11419237

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.