Evidence map›Paper›PMID 39314770›Full record

ArticleFrontiers in cardiovascular medicine2024

Blood pressure, brain lesions and cognitive decline in patients with atrial fibrillation.

Désirée Carmine, Stefanie Aeschbacher, Michael Coslovsky, Elisa Hennings, Rebecca E Paladini, Raffaele Peter, Melanie Burger, Tobias Reichlin, Nicolas Rodondi, Andreas S Müller and 16 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02105844 (Swiss Atrial Fibrillation Cohort Study - SWISS AF), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02105844 active not recruitingnot on this map

Swiss Atrial Fibrillation Cohort Study - SWISS AF

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2014 to 2030Enrolled2,415ConditionsAtrial Fibrillation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Désirée CarmineCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Stefanie AeschbacherCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Michael CoslovskyCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Elisa HenningsCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Rebecca E PaladiniCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Raffaele PeterCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Melanie BurgerCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Tobias ReichlinDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Nicolas RodondiInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Andreas S MüllerDepartment of Cardiology, Triemli Hospital Zürich, Zürich, Switzerland.
Peter AmmannDepartment of Cardiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Giulio ConteDivision of Cardiology, Ente Ospedaliero Cantonale (EOC), Cardiocentro Ticino Institute, Regional Hospital of Lugano, Lugano, Switzerland.
Angelo AuricchioDivision of Cardiology, Ente Ospedaliero Cantonale (EOC), Cardiocentro Ticino Institute, Regional Hospital of Lugano, Lugano, Switzerland.
Giorgio MoschovitisDivision of Cardiology, Ente Ospedaliero Cantonale (EOC), Cardiocentro Ticino Institute, Regional Hospital of Lugano, Lugano, Switzerland.
Julia B BardocziInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Annina StauberDepartment of Cardiology, Triemli Hospital Zürich, Zürich, Switzerland.
Maria Luisa De PernaDivision of Cardiology, Ente Ospedaliero Cantonale (EOC), Cardiocentro Ticino Institute, Regional Hospital of Lugano, Lugano, Switzerland.
Christine S ZuernCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Tim SinneckerDepartment of Neurology and Stroke Center, University Hospital Basel, University of Basel, Basel, Switzerland.
Patrick BadertscherCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Christian SticherlingCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Leo H BonatiResearch Department, Reha Rheinfelden, Rheinfelden, Switzerland.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Philipp KrisaiCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Stefan OsswaldCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Michael KühneCardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The influence of atrial fibrillation (AF) and blood pressure (BP) on brain lesions and cognitive function is unclear. We aimed to investigate the association of BP with different types of brain lesions and cognitive decline in patients with AF. Methods: Overall, 1,213 AF patients underwent standardized brain magnetic resonance imaging at baseline and after 2 years, as well as yearly neurocognitive testing. BP was measured at baseline and categorized according to guidelines. New lesions were defined as new or enlarged brain lesions after 2 years. We defined cognitive decline using three different neurocognitive tests. Logistic and Cox regression analyses were performed to examine the associations of BP with new brain lesions and cognitive decline. Results: The mean age was 71 ± 8.4 years, 74% were male and mean BP was 135 ± 18/79 ± 12 mmHg. New ischemic lesions and white matter lesions were found in 5.4% and 18.4%, respectively. After multivariable adjustment, BP was not associated with the presence of new brain lesions after 2 years. There was no association between BP and cognitive decline over a median follow-up of 6 years when using the Montreal Cognitive Assessment or Digit Symbol Substitution Test. However, BP categories were inversely associated with cognitive decline using the Semantic Fluency Test, with the strongest association in patients with hypertension grade 1 [Hazard Ratio (95% Confidence Interval) 0.57(0.42 to 0.77)], compared to patients with optimal BP (p for linear trend: 0.025). Conclusions: In a large cohort of AF patients, there was no association between BP and incidence of brain lesions after 2 years. Also, there was no consistent association between BP and cognitive decline over a follow-up of 6 years. Clinical Trial Registration: https://clinicaltrials.gov/study/NCT02105844, Identifier (NCT02105844).

Indexed as

atrial fibrillationblood pressurebrain lesionscognitive declinehypertension

Identifiers

PMID39314770
PMCPMC11417621

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.