Evidence map›Paper›PMID 39314673›Full record

ArticleJAMIA open2024

The impact of laboratory data missingness on sepsis diagnosis timeliness.

Jonathan Y Lam, Aaron Boussina, Supreeth P Shashikumar, Robert L Owens, Shamim Nemati, Christopher S Josef

Abstract read
In one paragraph

Article in JAMIA open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan Y LamDepartment of Biomedical Informatics, University of California San Diego, La Jolla, CA 92093, United States.ORCID https://orcid.org/0000-0001-9579-0604
Aaron BoussinaDepartment of Biomedical Informatics, University of California San Diego, La Jolla, CA 92093, United States.ORCID https://orcid.org/0000-0003-0944-5906
Supreeth P ShashikumarDepartment of Biomedical Informatics, University of California San Diego, La Jolla, CA 92093, United States.ORCID https://orcid.org/0000-0002-0348-4261
Robert L OwensDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, La Jolla, CA 92093, United States.
Shamim NematiDepartment of Biomedical Informatics, University of California San Diego, La Jolla, CA 92093, United States.
Christopher S JosefHealcisio, Inc, San Diego, CA 92093, United States.ORCID https://orcid.org/0000-0001-9368-6926

Funding

San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
GeneRAlizable Sepsis Phenotyping (GRASP) using Electronic Health Records and Continuous Monitoring SensorsR35GM143121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEMATI, SHAMIM · 2021 to 2025
$2.2M
RAAB-AI: Reducing Automation and Anchoring Bias in AI SystemsR01LM013998 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2022 to 2026
$1.7M
AIVIS: Next Generation Vigilant Information Seeking Artificial Intelligence-based Clinical Decision Support for SepsisR42AI177108 · NIAID · HEALCISIO, INC. · PI JOSEF, CHRISTOPHER · 2023 to 2024
$1.3M
NHLBI NIH HHS R01 HL157985NIAID NIH HHS R42 AI177108NIGMS NIH HHS R35 GM143121NLM NIH HHS R01 LM013998NLM NIH HHS T15 LM011271
6 · The paper itself

Abstract

Objective: To investigate the impact of missing laboratory measurements on sepsis diagnostic delays. Materials and Methods: In adult patients admitted to 2 University of California San Diego (UCSD) hospitals from January 1, 2021 to June 30, 2024, we evaluated the relative time of organ failure ( Results: Of the patients studied, 48.7% ( Discussion: Our study identified many sepsis patients with missing laboratory results vital for the identification of organ failure and the diagnosis of sepsis at or before the time of clinical suspicion of sepsis. Addressing data missingness via more timely laboratory assessment could precipitate an earlier recognition of organ failure and potentially earlier diagnosis of and treatment initiation for sepsis. Conclusions: More prompt laboratory assessment might improve the timeliness of sepsis recognition and treatment.

Indexed as

adultscriteriacritical careguidelinessepsis

Identifiers

PMID39314673
PMCPMC11418648

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.