Cardiac and mediastinum involvement in Burkholderia thailandensis infection: A case report and literature review.

Melioidosis, an infectious disease caused by Burkholderia pseudomallei, is prevalent in Southeast Asia and Northern Australia, presenting various clinical manifestations from asymptomatic to life-threatening infections. Although primarily affecting the lungs, intra-abdominal viscera, and musculoskeletal system, melioidosis can rarely involve the heart and mediastinum, which pose significant diagnostic and therapeutic challenges. Herein, we present the case of a 53-year-old male farmer who presented with persistent fever and chest pain, progressing to pericarditis and cardiac tamponade. Imaging revealed necrotic mediastinal lymphadenopathy and an enhancing pericardium with pericardial effusion. The patient underwent emergency surgical drainage and was treated with intravenous followed by oral antibiotics. Culture confirmed Burkholderia thailandensis, a closely related but less commonly reported species. This report highlights the complexities of diagnosing and managing B. thailandensis, which can mimic aortic disease, tuberculosis, malignancies, and other inflammatory conditions, especially in endemic areas, emphasizing the need for prompt medical and surgical treatment to improve patient outcomes.