Evidence map›Paper›PMID 39314508›Full record

ArticleArXiv2024

Initial Experience of Metabolic Imaging with Hyperpolarized [1-

Xiaoxi Liu, Ying-Chieh Lai, Di Cui, Shiang-Cheng Kung, Meyeon Park, Laszik Zoltan, Peder E Z Larson, Zhen J Wang

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Xiaoxi LiuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Ying-Chieh LaiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Di CuiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Shiang-Cheng KungDepartment of Medicine, University of California San Francisco Medical Center, San Francisco, California, USA.
Meyeon ParkDepartment of Medicine, University of California San Francisco Medical Center, San Francisco, California, USA.
Laszik ZoltanDepartment of Pathology, University of California San Francisco Medical Center, San Francisco, California, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Zhen J WangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor AggressivenessR01CA249909 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL, WANG, ZHEN JANE · 2021 to 2025
$3.2M
Upgrade of an Obsolete 3.35T DNP Polarizer to enable new HP C-13 Technology DevelopmentS10OD025077 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 2020 to 2020
$1.7M
Hyperpolarized 13C Metabolic MRI for Noninvasive Monitoring of Kidney InjuryR21DK130002 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL, WANG, ZHEN JANE · 2021 to 2022
$444k
NCI NIH HHS R01 CA249909NIBIB NIH HHS P41 EB013598NIDDK NIH HHS R21 DK130002NIH HHS S10 OD025077
6 · The paper itself

Abstract

backgroundKidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage. PURPOSE: To investigate the feasibility of hyperpolarized (HP) [1- STUDY TYPE: Prospective. SUBJECTS: 6 participants (mean age, 45.2 ± 12.4 years, 2 females) scheduled for kidney allograft biopsy and 5 patients (mean age, 59.6 ± 10.4 years, 2 females) with renal cell carcinoma (RCC). FIELD STRENGTH/SEQUENCE: 3 Tesla, T2-weighted fast spin echo, multi-echo gradient echo, single shot diffusion-weighted echo-planar imaging, and time-resolved HP ASSESSMENT: Five of the six kidney allograft participants underwent biopsy after MRI. Estimated glomerular filtration rate (eGFR) and urine protein-to-creatine ratio (uPCR) were collected within 4 weeks of MRI. Kidney metabolism was quantified from HP [1- STATISTICAL TESTS: Descriptive statistics (mean ± standard deviation).

resultsBiopsy was performed a mean of 9 days (range 5-19 days) after HP [1- DATA

conclusionStable allografts with normal findings at biopsy showed lactate-to-pyruvate ratios similar to native non-tumor bearing kidneys, whereas allografts with abnormal findings showed higher lactate-to-pyruvate ratios.

Indexed as

[1-13C]lactate[1-13C]pyruvateHyperpolarized 13Ckidney transplant

Identifiers

PMID39314508
PMCPMC11419194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.