Evidence map›Paper›PMID 39314493›Full record

ArticlebioRxiv : the preprint server for biology2025

Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers.

Juan I Bravo, Lucia Zhang, Bérénice A Benayoun

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Juan I BravoLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-9429-0488
Lucia ZhangLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0004-9212-7689
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-7401-4777

Funding

USC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3M
Understanding the regulation and impact of transposable elements in Vertebrate health and diseaseR35GM142395 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2021 to 2025
$2.2M
NIA NIH HHS T32 AG052374NIGMS NIH HHS R35 GM142395
6 · The paper itself

Abstract

LINE-1 (L1) and Alu are two families of transposable elements (TEs) occupying ~17% and ~11% of the human genome, respectively. Though only a small fraction of L1 copies is able to produce the machinery to mobilize autonomously, Alu and degenerate L1s can hijack their functional machinery and mobilize

Indexed as

AluGWASinsertionsLINE-1regulatorstransposons

Identifiers

PMID39314493
PMCPMC11419044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.