Evidence map›Paper›PMID 39314488›Full record

ArticlebioRxiv : the preprint server for biology2024

A secondary β-hydroxybutyrate metabolic pathway linked to energy balance.

Maria Dolores Moya-Garzon, Mengjie Wang, Veronica L Li, Xuchao Lyu, Wei Wei, Alan Sheng-Hwa Tung, Steffen H Raun, Meng Zhao, Laetitia Coassolo, Hashim Islam and 17 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Maria Dolores Moya-GarzonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Mengjie WangUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Veronica L LiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Xuchao LyuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Wei WeiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Alan Sheng-Hwa TungDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Steffen H RaunDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Meng ZhaoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Laetitia CoassoloDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Hashim IslamSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Barbara OliveiraSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Yuqin DaiSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Jan SpaasDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Antonio Delgado-GonzalezDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Kenyi DonosoDepartment of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Aurora Alvarez-BuyllaDepartment of Biology, Stanford University, Stanford, CA, USA.
Francisco Franco-MontalbanDepartamento de Química Farmacéutica y Orgánica, Universidad de Granada, Campus de Cartuja sn, 18011, Granada, Spain.
Anudari LetianDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Catherine WardStanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Lichao LiuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Katrin J SvenssonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Emily L GoldbergDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Christopher D GardnerStanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jonathan P LittleSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Steven M BanikDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Yong XuUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Jonathan Z LongDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Mechanisms controlling fructose uptake and utilizationR01DK125260 · NIDDK · STANFORD UNIVERSITY · PI Katrin Jennifer Svensson · 2020 to 2026
$3.5M
Chemical control of energy metabolism by N-acyl amino acidsR01DK124265 · NIDDK · STANFORD UNIVERSITY · PI LONG, JONATHAN Z · 2020 to 2024
$2.0M
Molecular Pharmacology Training GrantT32GM113854 · NIGMS · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2015 to 2019
$1.1M
The role of circulating Slit2 in adipose thermogenesis and diabetesR00DK111916 · NIDDK · STANFORD UNIVERSITY · PI SVENSSON, KATRIN JENNIFER · 2018 to 2020
$731k
The role of circulating Slit2 in adipose thermogenesis and diabetesK99DK111916 · NIDDK · DANA-FARBER CANCER INST · PI SVENSSON, KATRIN JENNIFER · 2016 to 2017
$180k
Nutrition Regulates Sexual FunctionF32HD112123 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI WANG, MENGJIE · 2024 to 2025
$131k
American Heart Association-American Stroke Association 24POST1196199NICHD NIH HHS F32 HD112123NIDDK NIH HHS K99 DK111916NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R00 DK111916NIDDK NIH HHS R01 DK124265NIDDK NIH HHS R01 DK125260NIGMS NIH HHS T32 GM113854
6 · The paper itself

Abstract

β-hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve interconversion of BHB and primary energy intermediates. Here we show that CNDP2 controls a previously undescribed secondary BHB metabolic pathway via enzymatic conjugation of BHB and free amino acids. This BHB-ylation reaction produces a family of endogenous ketone metabolites, the BHB-amino acids. Genetic ablation of CNDP2 in mice eliminates tissue amino acid BHB-ylation activity and reduces BHB-amino acid levels. Administration of BHB-Phe, the most abundant BHB-amino acid, to obese mice activates neural populations in the hypothalamus and brainstem and suppresses feeding and body weight. Conversely, CNDP2-KO mice exhibit increased food intake and body weight upon ketosis stimuli. CNDP2-dependent amino acid BHB-ylation and BHB-amino acid metabolites are also conserved in humans. Therefore, the metabolic pathways of BHB extend beyond primary metabolism and include secondary ketone metabolites linked to energy balance.

Identifiers

PMID39314488
PMCPMC11418978

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.