Evidence map›Paper›PMID 39314485›Full record

ArticlebioRxiv : the preprint server for biology2024

Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease.

Ikechukwu B Jacob, Akinkunmi O Lawal, Salma S Mahmoud, Emerson M Kopsack, Erin S Reynolds, Qinghe Meng, Hongkuan Fan, Paul T Massa, Saravanan Thangamani, Hongpeng Jia and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ikechukwu B Jacob
Akinkunmi O Lawal
Salma S Mahmoud
Emerson M Kopsack
Erin S Reynolds
Qinghe Meng
Hongkuan Fan
Paul T Massa
Saravanan ThangamaniORCID 0000-0002-4269-5993
Hongpeng Jia
Guirong Wang

Funding

Mechanisms of differential susceptibility of human SP-B genetic variants to pneumonia and lung injuryR01HL136706 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI WANG, GUIRONG · 2017 to 2020
$1.6M
Roles of human surfactant collectin variants in the susceptibility of COVID-19R21AI171574 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI WANG, GUIRONG · 2022 to 2023
$448k
NHLBI NIH HHS R01 HL136706NIAID NIH HHS R21 AI171574
6 · The paper itself

Abstract

COVID-19 remains a significant threat to public health globally. Infection in some susceptible individuals causes life-threatening acute lung injury (ALI/ARDS) and/or death. Human surfactant protein A (SP-A) is a C-type lectin expressed in the lung and other mucosal tissues, and it plays a critical role in host defense against various pathogens. The human SP-A genes (

Identifiers

PMID39314485
PMCPMC11418998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.