Evidence map›Paper›PMID 39314477›Full record

ArticlebioRxiv : the preprint server for biology2025

NuRD chromatin remodeling is required to repair exogenous DSBs in the

Deepshikha Ananthaswamy, Kelin Funes, Thiago Borges, Scott Roques, Nina Fassnacht, Sereen El Jamal, Paula M Checchi, Teresa Wei-Sy Lee

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Deepshikha AnanthaswamyDepartment of Biological Sciences, University of Massachusetts Lowell, 198 Riverside Dr. Lowell MA, 01854.ORCID 0009-0002-7805-9101
Kelin FunesDepartment of Biological Sciences, University of Massachusetts Lowell, 198 Riverside Dr. Lowell MA, 01854.ORCID 0009-0009-2689-6080
Thiago BorgesDepartment of Biological Sciences, University of Massachusetts Lowell, 198 Riverside Dr. Lowell MA, 01854.ORCID 0009-0008-9553-7383
Scott RoquesDepartment of Biological Sciences, University of Massachusetts Lowell, 198 Riverside Dr. Lowell MA, 01854.ORCID 0009-0004-6906-080X
Nina FassnachtDepartment of Biology, Marist College, 3399 North Road, Poughkeepsie, NY 12601.
Sereen El JamalDepartment of Biology, Marist College, 3399 North Road, Poughkeepsie, NY 12601.
Paula M ChecchiDepartment of Biology, Marist College, 3399 North Road, Poughkeepsie, NY 12601.ORCID 0000-0002-7115-4934
Teresa Wei-Sy LeeDepartment of Biological Sciences, University of Massachusetts Lowell, 198 Riverside Dr. Lowell MA, 01854.ORCID 0000-0002-0149-5389

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Choose Development! to broaden participation of underrepresented undergraduates in developmental biology researchR25HD105600 · NICHD · SOCIETY FOR DEVELOPMENTAL BIOLOGY · PI UNGUEZ, GRACIELA ALEXANDRA · 2021 to 2025
$734k
Research Supplement to promote diversity for parent grant: Linking transgenerational epigenetic inheritance to gene expression and lifespan in C. elegansR15GM144861 · NIGMS · UNIVERSITY OF MASSACHUSETTS LOWELL · PI LEE, TERESA WEI-SY · 2021 to 2023
$406k
Chromatin-mediated maintenance of genomic integrity in germ cellsR15HD104115 · NICHD · MARIST COLLEGE · PI CHECCHI, PAULA M, DENNIS, MEGAN KATHLEEN · 2021 to 2021
$346k
Role of Higher Order Chromatin Structure in Gamete FormationR15GM117479 · NIGMS · MARIST COLLEGE · PI CHECCHI, PAULA M · 2016 to 2016
$332k
NICHD NIH HHS R15 HD104115NICHD NIH HHS R25 HD105600NIGMS NIH HHS R15 GM117479NIGMS NIH HHS R15 GM144861NIH HHS P40 OD010440
6 · The paper itself

Abstract

Organisms rely on coordinated networks of DNA repair pathways to protect genomes against toxic double-strand breaks (DSBs), particularly in germ cells. All repair mechanisms must successfully negotiate the local chromatin environment in order to access DNA. For example, nucleosomes can be repositioned by the highly conserved Nucleosome Remodeling and Deacetylase (NuRD) complex. In

Indexed as

DNA repairFCD-2/FANCD2germlineLET-418/CHD4NuRD (nucleosome remodeling and deacetylase complex)

Identifiers

PMID39314477
PMCPMC11419128

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.