Evidence map›Paper›PMID 39314441›Full record

ArticlebioRxiv : the preprint server for biology2024

CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing.

Basheer Becerra, Sandra Wittibschlager, Zain M Patel, Ana P Kutschat, Justin Delano, Eric Che, Anzhelika Karjalainen, Ting Wu, Marlena Starrs, Martin Jankowiak and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Basheer BecerraBioinformatics and Integrative Genomics PhD Program, Harvard Medical School, Boston, MA, USA.
Sandra WittibschlagerSt. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Zain M PatelBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ana P KutschatSt. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Justin DelanoBioinformatics and Integrative Genomics PhD Program, Harvard Medical School, Boston, MA, USA.
Eric CheBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Anzhelika KarjalainenSt. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ting WuDivision of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Marlena StarrsDivision of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Martin JankowiakBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel E BauerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Davide SeruggiaSt. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Luca PinelloBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1109-3823

Funding

Comprehensive characterization of variants underlying heart and blood diseases with CRISPR base editingUM1HG012010 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel Evan Bauer, Luca Pinello · 2021 to 2026
$10.4M
Multiscale exploration of the functional non-coding genomeR35HG010717 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI PINELLO, LUCA · 2019 to 2023
$2.6M
NHGRI NIH HHS R35 HG010717NHGRI NIH HHS UM1 HG012010
6 · The paper itself

Abstract

CRISPR tiling screens have advanced the identification and characterization of regulatory sequences but are limited by low resolution arising from the indirect readout of editing via guide RNA sequencing. This study introduces

Identifiers

PMID39314441
PMCPMC11419122

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.