Evidence map›Paper›PMID 39314427›Full record

ArticlebioRxiv : the preprint server for biology2025

The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasis.

Syeda Kubra, Michelle Sun, William Dion, Ahmet Catak, Hannah Luong, Haokun Wang, Yinghong Pan, Jia-Jun Liu, Aishwarya Ponna, Lijun Liu and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Syeda KubraAging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.ORCID 0000-0003-0842-7562
Michelle SunAging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
William DionAging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
Ahmet CatakAging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
Hannah LuongAging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
Haokun WangAging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
Yinghong PanUPMC Genome Center, UPMC, Pittsburgh, PA, U.S.A.
Jia-Jun LiuPittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Aishwarya PonnaAging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
Lijun LiuPittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Ian SipulaDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
Jian-Hua LuoPittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Michael J JurczakDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
Silvia LiuPittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Bokai ZhuAging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.ORCID 0000-0003-0827-5757

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLAUDETTE Marie ST CROIX · 2019 to 2026
$10.9M
Decoding the regulation and functions of mammalian 12h-clockDP2GM140924 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHU, BOKAI · 2020 to 2020
$2.4M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
Ultradian to circadian transcriptome re-wiring underlies liver agingR21AG071893 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHU, BOKAI · 2022 to 2023
$437k
Nuclear speckle liquid-liquid phase separation dynamics in senescence and agingF31AG080998 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DION, WILLIAM AARON · 2023 to 2025
$117k
NIA NIH HHS F31 AG080998NIA NIH HHS R21 AG071893NIDDK NIH HHS P30 DK120531NIGMS NIH HHS DP2 GM140924NIH HHS S10 OD028483
6 · The paper itself

Abstract

Proteostasis is vital for cellular health, with disruptions leading to aging, neurodegeneration and metabolic disorders. Traditionally, proteotoxic stress responses were studied as acute reactions to various noxious factors; however, recent evidence reveals that many proteostasis genes exhibit ~12h ultradian rhythms under physiological conditions in mammals, driven by an XBP1s-dependent 12h oscillator. By examining the chromatin landscape of this oscillator, we identified RBBP5 as an essential epigenetic regulator of global proteostasis dynamics. Mechanistically, as the core subunit of the SET1/COMPASS complex, RBBP5 co-activates XBP1s to facilitate dynamic proteostasis gene expression by marking promoter-proximal H3K4me3, which further recruits the Integrator Complex and SWI/SNF chromatin remodelers. Functionally, RBBP5 is indispensable for regulating both the 12h oscillator and acute transcriptional response to various proteotoxic stresses, including ER stress and nutrient deprivation. RBBP5 ablation causes increased susceptibility to proteotoxic stress, chronic inflammation, and hepatic steatosis in mice, along with impaired autophagy and reduced cell survival

Identifiers

PMID39314427
PMCPMC11419162

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.