Evidence map›Paper›PMID 39314417›Full record

ArticlebioRxiv : the preprint server for biology2024

Sphingosine kinase 1 is induced by glucocorticoids in adipose derived stem cells and enhances glucocorticoid mediated signaling in adipose expansion.

Johana Lambert, Anna Kovilakath, Maryam Jamil, Yolander Valentine, Andrea Anderson, David Montefusco, L Ashley Cowart

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Johana LambertDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0002-7468-7146
Anna KovilakathDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0003-0735-9131
Maryam JamilDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0009-0006-3240-0027
Yolander ValentineDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0001-8082-7734
Andrea AndersonDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.
David MontefuscoDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0003-4217-4378
L Ashley CowartDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0002-5312-5232

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0M
Multi-Disciplinary Training Program in Translational Cardiovascular ResearchT32HL149645 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Lauren Ashley Cowart, William Gregory Hundley · 2020 to 2026
$2.2M
Novel sphingolipid metabolites in myocardial ischemiaR01HL151243 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI COWART, LAUREN ASHLEY · 2020 to 2024
$1.9M
Sphingolipids in Diabetic CardiomyopathyR01HL117233 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI COWART, LAUREN ASHLEY · 2014 to 2018
$1.9M
Sptlc3-derived sphingolipids in cardiomyocyte death in ischemiaF31HL156529 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KOVILAKATH, ANNA PHILIP · 2021 to 2023
$119k
Sphingolipids in the Pathophysiology of Obesity and DiabetesI01BX000200 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI COWART, LAUREN ASHLEY · 2009 to 2025
–
BLRD Research Career Scientist Award ApplicationIK6BX006315 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI COWART, LAUREN ASHLEY · 2023 to 2025
–
BLRD VA I01 BX000200BLRD VA IK6 BX006315NCI NIH HHS P30 CA016059NHLBI NIH HHS F31 HL156529NHLBI NIH HHS R01 HL117233NHLBI NIH HHS R01 HL151243NHLBI NIH HHS T32 HL149645
6 · The paper itself

Abstract

Sphingosine kinase 1 (SphK1) plays a crucial role in regulating metabolic pathways within adipocytes and is elevated in the adipose tissue of obese mice. While previous studies have reported both pro- and inhibitory effects of SphK1 and its product, sphingosine-1-phosphate (S1P), on adipogenesis, the precise mechanisms remain unclear. This study explores the timing and downstream effects of SphK1/S1P expression and activation during

Identifiers

PMID39314417
PMCPMC11419133

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.