ArticlebioRxiv : the preprint server for biology2024
The mitochondrial dicarboxylate carrier mediates in vivo hepatic gluconeogenesis.
Daniel J Pape, Kelly C Falls-Hubert, Ronald A Merrill, Adnan Ahmed, Qingwen Qian, Gavin R McGivney, Paulina Sobieralski, Adam J Rauckhorst, Ling Yang, Eric B Taylor
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Daniel J PapeDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Kelly C Falls-HubertDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Ronald A MerrillDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Adnan AhmedDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Qingwen QianDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Gavin R McGivneyDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Paulina SobieralskiDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Adam J RauckhorstDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.ORCID 0000-0002-4101-0075 Ling YangDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Eric B TaylorDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.ORCID 0000-0003-4549-6567 Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MMedical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4MDiabetes Research Training Program Diversity SupplementT32DK112751 · NIDDK · UNIVERSITY OF IOWA · PI Andrew W Norris · 2017 to 2026
$4.8MRegulation of Hepatic Macronutrient Metabolism by Mitochondrial Citrate TransportR01DK104998 · NIDDK · UNIVERSITY OF IOWA · PI TAYLOR, ERIC B · 2015 to 2022
$3.2MRole of ADH5 in the Regulation of Brown Adipose Tissue Metabolic HomeostasisR01DK126817 · NIDDK · UNIVERSITY OF IOWA · PI YANG, LING · 2022 to 2025
$2.0MRegulation of Hepatic Fuel Fluxes by the Mitochondrial Dicarboxylate CarrierR01DK138664 · NIDDK · UNIVERSITY OF IOWA · PI Eric B Taylor · 2024 to 2026
$1.5MNCI NIH HHS P30 CA086862NIDDK NIH HHS R01 DK104998NIDDK NIH HHS R01 DK126817NIDDK NIH HHS R01 DK138664NIDDK NIH HHS T32 DK112751NIGMS NIH HHS T32 GM007337NIGMS NIH HHS T32 GM139776
6 · The paper itselfAbstract
Hepatic gluconeogenesis (GNG) is essential for maintaining euglycemia during prolonged fasting. However, GNG becomes pathologically elevated and drives chronic hyperglycemia in type 2 diabetes (T2D). Lactate/pyruvate is a major GNG substrate known to be imported into mitochondria for GNG. Yet, the subsequent mitochondrial carbon export mechanisms required to supply the extra-mitochondrial canonical GNG pathway have not been genetically delineated. Here, we evaluated the role of the mitochondrial dicarboxylate carrier (DiC) in mediating GNG from lactate/pyruvate. We generated liver-specific DiC knockout (DiC LivKO) mice. During lactate/pyruvate tolerance tests, DiC LivKO decreased plasma glucose excursion and
Indexed as
DiabetesGluconeogenesis (GNG)LiverMetabolomicsMitochondrial dicarboxylate carrier (DiC)
Identifiers
PMID39314408
PMCPMC11419125
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