Evidence map›Paper›PMID 39314382›Full record

ArticlebioRxiv : the preprint server for biology2024

NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation.

Snehasis Das, Rohan Varshney, Jacob W Farriester, Gertrude Kyere-Davies, Alexandrea E Martinez, Kaitlyn Hill, Michael Kinter, Gregory P Mullen, Prabhakara R Nagareddy, Michael C Rudolph

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Snehasis DasDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-5269-9269
Rohan VarshneyDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Jacob W FarriesterDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Gertrude Kyere-DaviesDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Alexandrea E MartinezDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Kaitlyn HillDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Michael KinterAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Gregory P MullenDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Prabhakara R NagareddyDeptartment of Internal Medicine, Cardiovascular Section, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Michael C RudolphDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.

Funding

Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI David W Dyer · 2012 to 2026
$60.2M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Thrombocytopoiesis in Diabetes: Role of Damage Associated Molecular PatternsR01HL137799 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI NAGAREDDY, PRABHAKARA REDDY · 2018 to 2022
$3.2M
A dialogue between neutrophils and monocytes for effective resolution of inflammation following acute myocardial injuryR01HL156856 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Prabhakara Reddy Nagareddy · 2022 to 2026
$2.9M
5-Laser Cytek Aurora Spectral Flow CytometerS10OD028479 · OD · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI THOMPSON, LINDA F · 2020 to 2020
$317k
NHLBI NIH HHS R01 HL137799NHLBI NIH HHS R01 HL156856NIGMS NIH HHS P20 GM103447NIGMS NIH HHS R24 GM137786NIH HHS S10 OD028479
6 · The paper itself

Abstract

In humans, perinatal exposure to an elevated omega-6 (n6) relative to omega-3 (n3) Fatty Acid (FA) ratio is associated with the likelihood of childhood obesity. In mice, we show perinatal exposure to excessive n6-FA programs neonatal Adipocyte Stem-like cells (ASCs) to differentiate into adipocytes with lower mitochondrial nutrient oxidation and a propensity for nutrient storage. Omega-6 FA exposure reduced fatty acid oxidation (FAO) capacity, coinciding with impaired induction of beige adipocyte regulatory factors PPARγ, PGC1α, PRDM16, and UCP1. ASCs from n6-FA exposed pups formed adipocytes with increased lipogenic genes in vitro, consistent with an in vivo accelerated adipocyte hypertrophy, greater triacylglyceride accumulation, and increased % body fat. Conversely, n6-FA exposed pups had impaired whole animal

Indexed as

adipocyte stem-like cellsbeige adipocyte metabolismearly-life adipocyte developmentNR2F2omega-3 fatty acids

Identifiers

PMID39314382
PMCPMC11419096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.