Evidence map›Paper›PMID 39314352›Full record

ArticlebioRxiv : the preprint server for biology2024

Molecular basis of the urate transporter URAT1 inhibition by gout drugs.

Yang Suo, Justin G Fedor, Han Zhang, Kalina Tsolova, Xiaoyu Shi, Kedar Sharma, Shweta Kumari, Mario Borgnia, Peng Zhan, Wonpil Im and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yang SuoDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, USA.
Justin G FedorDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, USA.
Han ZhangDepartments of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, 18015, USA.
Kalina TsolovaDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, USA.
Xiaoyu ShiDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012 Shandong, P.R. China.
Kedar SharmaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Shweta KumariDepartments of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, 18015, USA.
Mario BorgniaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Peng ZhanDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012 Shandong, P.R. China.
Wonpil ImDepartments of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, 18015, USA.
Seok-Yong LeeDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, USA.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
NIEHS Cryo-EM Core FacilityZICES103326 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BORGNIA, MARIO · 2017 to 2025
$17.0M
Intramural NIH HHS ZIC ES103326NCI NIH HHS 75N91019D00024NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Hyperuricemia is a condition when uric acid, a waste product of purine metabolism, accumulates in the blood

Identifiers

PMID39314352
PMCPMC11419087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.