Evidence map›Paper›PMID 39314274›Full record

ArticlebioRxiv : the preprint server for biology2024

Cell-type-specific splicing of transcription regulators and

Xiangbin Ruan, Kaining Hu, Yalan Yang, Runwei Yang, Elizabeth Tseng, Bowei Kang, Aileen Kauffman, Rong Zhong, Xiaochang Zhang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xiangbin RuanDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Kaining HuDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Yalan YangDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Runwei YangDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Elizabeth TsengPacific Biosciences, Menlo Park, CA 94025, USA.
Bowei KangDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Aileen KauffmanDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Rong ZhongDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Xiaochang ZhangDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-5768-7470

Funding

Single cell detection of dynamic protein-RNA interactionDP2GM137423 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHANG, XIAOCHANG · 2019 to 2019
$2.4M
Rescuing SYNGAP1 haploinsufficiency by redirecting alternative splicingR01MH130594 · NIMH · UNIVERSITY OF CHICAGO · PI Xiaochang Zhang · 2023 to 2026
$2.4M
Mechanisms of Cell-type-specific pre-mRNA SplicingR35GM152177 · NIGMS · UNIVERSITY OF CHICAGO · PI Xiaochang Zhang · 2024 to 2026
$1.4M
NIGMS NIH HHS DP2 GM137423NIGMS NIH HHS R35 GM152177NIMH NIH HHS R01 MH130594
6 · The paper itself

Abstract

How master splicing regulators crosstalk with each other and to what extent transcription regulators are differentially spliced remain unclear in the developing brain. Here, cell-type-specific RNA-Seq of the developing neocortex uncover that transcription regulators are enriched for differential splicing, altering protein isoforms or inducing nonsense-mediated mRNA decay. Transient expression of Rbfox proteins in radial glia progenitors induces neuronal splicing events preferentially in transcription regulators such as

Indexed as

full-length isoformslong-read RNA-Seqmultiplexed CRISPR editingNeuNneuronal migrationunproductive splicing

Identifiers

PMID39314274
PMCPMC11419088

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.