Evidence map›Paper›PMID 39314271›Full record

ArticlebioRxiv : the preprint server for biology2024

Single-cell analysis of human airway epithelium identifies cell type-specific responses to

Alfred T Harding, Arianne J Crossen, Jennifer L Reedy, Kyle J Basham, Olivia W Hepworth, Yanting Zhang, Viral S Shah, Hannah Brown Harding, Manalee V Surve, Patricia Simaku and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Alfred T HardingInstitute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge MA.
Arianne J CrossenDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jennifer L ReedyDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kyle J BashamDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Olivia W HepworthDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Yanting ZhangDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Viral S ShahHarvard Stem Cell Institute, Cambridge, MA, USA.
Hannah Brown HardingDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Manalee V SurveHarvard Stem Cell Institute, Cambridge, MA, USA.
Patricia SimakuDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Geneva N KwakuDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kristine Nolling JensenDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Yohana OttoCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Rebecca A WardDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6752-5600
George R ThompsonDivision of Infectious Diseases, and Departments of Internal Medicine and Medical Microbiology and Immunology, University of California-Davis, Sacramento, CA, USA.
Bruce S KleinDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Jayaraj RajagopalHarvard Stem Cell Institute, Cambridge, MA, USA.
Pritha SenDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Adam L HaberDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA USA.ORCID 0000-0002-4229-2852
Jatin M VyasDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-9985-9565

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4M
Molecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9M
Control of Type I Interferon Production in Response to Candida albicansR01AI150181 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jatin M Vyas · 2020 to 2026
$5.4M
Progenitors, Mechanisms of Differentiation, and Functions of Lung M CellsR01HL164563 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RAJAGOPAL, JAYARAJ · 2022 to 2025
$3.2M
The Functional Role of the Tetraspanin CD82/Kai1 in Fungal Innate ImmunityR01AI136529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2018 to 2022
$2.7M
Mechanisms of vaccine immunity against coccidioidomycosisR01AI168370 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2023 to 2026
$2.2M
High-dimensional single-cell mapping to define immune signatures of cytomegalovirus-associated rejection in cardiac transplantationK08HL157725 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SEN, PRITHA · 2021 to 2025
$929k
Host Responses to Coccidioides by Human Airway EpitheliumR21AI152499 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2022 to 2023
$462k
NHLBI NIH HHS K08 HL157725NHLBI NIH HHS R01 HL164563NIAID NIH HHS R01 AI040996NIAID NIH HHS R01 AI136529NIAID NIH HHS R01 AI150181NIAID NIH HHS R01 AI168370NIAID NIH HHS R21 AI152499NIAID NIH HHS R37 AI035681NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

Respiratory fungal infections pose a significant threat to human health. Animal models do not fully recapitulate human disease, necessitating advanced models to study human-fungal pathogen interactions. In this study, we utilized primary human airway epithelial cells (hAECs) to recapitulate the lung environment

Identifiers

PMID39314271
PMCPMC11418999

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.