ArticleClinical cardiology2024
Associations Between Cardiovascular Health (Life's Essential 8) and Mental Disorders.
Article in Clinical cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship between cardiovascular health and common mental disorders among adults aged ≤ 50 years: a systematic review of observational studies.BMC psychiatry · 2026Pooled it
- Life's essential 8 health profiles and risk of incident neuropsychiatric diseases: a nationwide prospective cohort study.BMC psychiatry · 2026Article
- Association Between Life's Crucial 9 and the prevalence of coronary heart disease in U.S. adults: the potential role of the systemic inflammatory response index.BMC cardiovascular disorders · 2026Article
- Life's Essential 8 and Suicide Risk: A Population-Level Study of Cardiovascular Health as a Mental Health Indicator.Psychiatry investigation · 2026Article
- Physical activity and weight are important predictors of health related quality of life in adults with congenital heart disease.International journal of cardiology. Congenital heart disease · 2025Article
- The link between systemic inflammation and mental disorders: a study on CLR, depression, and anxiety in a US cohort.Frontiers in psychiatry · 2025Article
- Adherence to Life's Essential 8 enhances gut microbiota diversity and cognitive performance.Frontiers in microbiomes · 2025Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundMental health was closely associated with cardiovascular disease (CVD). We aimed to investigate the association between cardiovascular health (CVH), as defined by Life's Essential 8 (LE8), and the presence of depression and anxiety. HYPOTHESIS: We hypothesized that CVH, as defined by LE8, was negatively associated with the prevalence of depression and anxiety.
methodsA cross-sectional study was conducted on participants (≥ 20 years old) from the National Health and Nutrition Examination Survey (NHANES). The LE8 score (ranging from 0 to 100) was composed of the health behavior score and the health factor score, which were further categorized into three levels as follows: low (0-49), moderate (50-79), and high (80-100). Weighted multivariable logistic regressions and restricted cubic splines were utilized to assess the association between LE8 and mental disorders.
resultsAmong the 13 028 participants included in this research, 1206 were determined to have depression symptoms and 2947 were determined to have anxiety symptoms. In the weighted and adjusted model, LE8 was negatively associated with the prevalence of depression (odds ratio [OR], 95% confidence interval [CI]: 0.61, 0.58-0.65) and anxiety (OR, 95% CI: 0.78, 0.75-0.81). Furthermore, a nonlinear dose-response relationship was observed between LE8 and anxiety.
conclusionsCVH defined by the LE8 was independently and negatively associated with the prevalence of depression and anxiety. Interventions targeting LE8 components may improve both CVH and mental health.
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