Evidence map›Paper›PMID 39313887›Full record

ArticleInfectious disorders drug targets2025

Interaction of High- and Low-Risk Human Papillomavirus Genotypes is Associated with a Reduced Risk of Developing Cervical Cancer.

Malihe Hasanzadeh, Marzieh Rejali, Ghazaleh Khalili-Tanha, Mehraneh Mehramiz, Negar Yavari, Elham Nazari, Parnian Malakuti, Faezeh Maleki, Ghazaleh Ghorbannezhad, Mahdi Rafiei and 10 more

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Article in Infectious disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Malihe HasanzadehDepartment of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Marzieh RejaliMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Ghazaleh Khalili-TanhaMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mehraneh MehramizMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Negar YavariMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Elham NazariMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Parnian MalakutiMedical Student, Faculty of Medicine, Szeged University of Medical Sciences, Szeged, Hungary.
Faezeh MalekiMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Ghazaleh GhorbannezhadMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahdi RafieiMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Anahita MiraniMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Negar Gholampoor-ShamkaniMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Hoda SaberMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Leila Mousavi-SereshtBasic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Zohreh Emamdadi-AliabadMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra MahdianMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahdieh AkbariMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Gordon A FernsBrighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK.
Ala-Eddin Al MoustafaCollege of Medicine, QU Health, Qatar University, Doha, Qatar.
Amir AvanMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

Mashhad University of Medical Sciences, Iran 960282
6 · The paper itself

Abstract

introductionCervical cancer is among the most common types of cancer in women and is associated with human papillomavirus (HPV) infection. The association between cervical cancer and high-risk HPV infection has been well documented. However, the effect of simultaneous infection with high- and low-risk HPV or low-risk HPV alone on the risk of developing cervical malignancy remains unanswered in guidelines.

methodWe investigated the association of high and low-risk HPVs (HR or LR) genotypes with cervical carcinoma risk and pathological and cytological information in cases recruited from a population- based cohort study of 790 patients. Correlation matrix and t-test were used for analysis.

resultsThe percentage of HR+LR and HR-HPV16/18 were 9.30% and 11.20% in class II, 7.15% and 7.10% in class IV, and 7.15% and 5.80% in As-CUS smears. Interestingly, concurrent infection with HR-HPV and LR-HPV types led to a significant reduction in the risk of developing malignancy compared to the high-risk group (OR=0.3 (0.098-0.925), pvalue= 0.04). The percentage of individuals with cervical malignancy was 10.2% and 28.2% within the co-infected and the HR-HPV participants.

conclusionOur findings suggest that simultaneous infection with high- and low-risk HPV may reduce the risk of cervical malignancy.

Indexed as

PapillomaviridaePapillomavirus InfectionsUterine Cervical NeoplasmsAdultAgedCohort StudiesCoinfectionFemaleGenotypeHuman papillomavirus 16Human papillomavirus 18Human Papillomavirus VirusesHumansMiddle AgedRisk FactorsCervical cancercorrelation matrixhigh-risk HPVhuman papillomaviruslow-risk HPt-test analysis.

Identifiers

PMID39313887

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.