Evidence map›Paper›PMID 39313764›Full record

ArticleMagnetic resonance in medicine2025

In vivo cardiac diffusion tensor imaging on an MR system featuring ultrahigh performance gradients with 200 mT/m maximum gradient strength.

Danielle Kara, Yuchi Liu, Shi Chen, Thomas Garrett, Arwa Younis, Masafumi Sugawara, Michael A Bolen, Xiaoming Bi, Oussama Wazni, Hiroshi Nakagawa and 2 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Danielle KaraCardiovascular Innovation Research Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0001-8369-798X
Yuchi LiuCardiovascular MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Malvern, Pennsylvania, USA.ORCID 0000-0003-3533-1697
Shi ChenCardiovascular Innovation Research Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0003-1719-0536
Thomas GarrettCardiovascular Innovation Research Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Arwa YounisDepartment of Cardiovascular & Metabolic Science, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Masafumi SugawaraDepartment of Cardiovascular & Metabolic Science, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Michael A BolenDiagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Xiaoming BiCardiovascular MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Malvern, Pennsylvania, USA.
Oussama WazniCardiovascular Medicine, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Hiroshi NakagawaCardiovascular Medicine, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Deborah KwonCardiovascular Innovation Research Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Christopher NguyenCardiovascular Innovation Research Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0003-1475-2329

Funding

Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4M
Microstructural Response of the Myocardium to Mechanical LoadR01HL159010 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI, NGUYEN, CHRISTOPHER T · 2021 to 2024
$3.2M
Improving Phenotypic Classification and Prediction of Treatment Outcomes in Patients with Non-ischemic Cardiomyopathy and Functional Mitral RegurgitationR01HL170090 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI DEBORAH KWON · 2023 to 2026
$3.1M
Modeling, measurement and prediction of cardiac magneto-stimulation thresholdsR01EB033853 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin, Christopher T Nguyen · 2023 to 2026
$2.4M
NHLBI NIH HHS NIH R01 HL151704NHLBI NIH HHS NIH R01 HL159010NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R01 HL159010NHLBI NIH HHS R01 HL170090NIBIB NIH HHS NIH R01 EB033853NIBIB NIH HHS R01 EB033853
6 · The paper itself

Abstract

purposeOur aim is to assess the potential of an MR system with ultrahigh performance gradients (200 mT/m maximum gradient strength) to address two interrelated challenges in cardiac DTI: low SNR and sensitivity to bulk motion.

methodsImaging was performed in 20 healthy volunteers, two patients, and one swine post-myocardial infarction. The impact of maximum gradient strength was assessed with spin echo cardiac DTI featuring second-order motion compensation and varying maximum system gradient strengths (40, 80, 200 mT/m). Motion compensation requirements at 200 mT/m were assessed with sequences featuring zeroth-, first-, and second-order motion compensation. SNR, mean diffusivity, fractional anisotropy, helix angle transmurality, and secondary eigenvector angle in the left ventricle were compared.

resultsIncreasing maximum system gradient strength from 40 and 80 mT/m to 200 mT/m increased SNR of b = 500 s/mm

conclusionUltrahigh performance gradients (200 mT/m) enable high SNR DWIs of the heart and resultant improvements in diffusion tensor metrics. Despite reduced diffusion-encoding duration, second-order motion compensation is required to overcome sensitivity to cardiac motion.

Indexed as

Diffusion Tensor ImagingAdultAnimalsFemaleHealthy VolunteersHeartHumansImage Processing, Computer-AssistedMaleMiddle AgedMotionMyocardial InfarctionReproducibility of ResultsSignal-To-Noise RatioSwinecardiac DTIcardiac MRdiffusion tensor imagingheartM2 motion compensationmotion‐compensated diffusion gradients

Identifiers

PMID39313764
PMCPMC11604833

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.