Synthesis, spectroscopic characterization, DFT calculations, in silico-ADMET and molecular docking analysis of novel quinoline-substituted 5H-chromeno [2,3-b] pyridine derivatives as antibacterial agents.

Rajesh Kancherla, T N Lohith, Sushma Deshmukh, Shekhar Reddy Mulka, Gouthami Kuruvalli, M B Madhusudana Reddy

Abstract read

In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rajesh KancherlaDepartment of Chemistry, School of Applied Sciences, REVA University, Bangalore, 560064, India.

T N LohithDepartment of Physics, The National Institute of Engineering (NIE), Mysore, Karnataka, 570008, India.

Sushma DeshmukhDepartment of Chemistry, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, 431606, India.

Shekhar Reddy MulkaDepartment of Analytical Chemistry, Accu Analytical, Hyderabad, Telangana, 500076, India.

Gouthami KuruvalliDepartment of Biotechnology, School of Applied Sciences, REVA University, Bangalore, 560064, India.

M B Madhusudana ReddyDepartment of Chemistry, School of Applied Sciences, REVA University, Bangalore, 560064, India. madhusudana.mb@reva.edu.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A convenient, straightforward, and effective one-step reaction for the synthesis of a three-component compound of biologically relevant novel 2,4-diamino-5-(8-hydroxyquinolin-7-yl)-5H-chromeno[2,3-b] pyridine-3-carbonitrile derivatives was designed and synthesized. The synthesis was developed by the reaction between salicylaldehyde 1, 8-hydroxyquinoline 2, 2-aminopropene-1,1,3-tricarbonitrile 3, and the catalytic amount of triethylamine in ethanol at 78 °C. This methodology has many beneficial features, including the use of inexpensive and non-hazardous starting materials, single-flask reactions, optimized reaction conditions, the termination of intermediate isolation, easy workup, reducing organic waste products, being chromatography-free, and decreasing the reaction time along with quantitative yields with high functional group tolerance. A proposed mechanism with supporting experimental data is presented, including

Indexed as

Anti-Bacterial AgentsMolecular Docking SimulationPyridinesQuinolinesDensity Functional TheoryDNA GyraseMicrobial Sensitivity TestsAnti-Bacterial AgentsDNA GyrasePyridinesquinolineQuinolines2-aminopropene-1,1,3-tricarbonitrile8-hydroxyquinolineAntibacterial activityChromeno[2,3-b] pyridinesDFT calculations and in silico ADMET and molecular docking analysisSalicylaldehyde

Identifiers

PMID39313710

DOI10.1007/s11030-024-10982-x

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.