Evidence map›Paper›PMID 39313708›Full record

ArticleEndocrine2025

Efficacy of postoperative radioactive iodine therapy for patients with low and intermediate risk papillary thyroid carcinoma.

Hyeon A Lee, Chang Myeon Song, Yong Bae Ji, Ji Young Kim, Soo Jin Lee, Yun Young Choi, Kyung Tae

Abstract read
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In one paragraph

Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyeon A LeeDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.ORCID 0000-0003-4452-8053
Chang Myeon SongDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.ORCID 0000-0001-5267-0135
Yong Bae JiDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.ORCID 0000-0002-0182-7865
Ji Young KimDepartment of Nuclear Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.ORCID 0000-0003-2199-4529
Soo Jin LeeDepartment of Nuclear Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.ORCID 0000-0002-5600-1315
Yun Young ChoiDepartment of Nuclear Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.ORCID 0000-0002-7535-4343
Kyung TaeDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea. kytae@hanyang.ac.kr.ORCID 0000-0002-0382-2072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the efficacy of postoperative radioactive iodine (RAI) and its impact on recurrence rates and survival benefits in low- to intermediate-risk papillary thyroid carcinoma (PTC).

methodsThis retrospective study involved the examination of 1286 patients diagnosed with low- to intermediate-risk PTC who underwent total thyroidectomy with or without neck dissection, supplemented with postoperative RAI therapy or not between the years 2000 and 2021.

resultsFrom the patient pool, 589 (45%) were classified as low-risk and 697 (55%) as intermediate-risk according to the 2015 American Thyroid Association guidelines. Among the low-risk group, 375 (63.7%) underwent postoperative RAI, while in the intermediate-risk group, 566 (82.2%) underwent the procedure. The overall survival and disease-free survival rates were not statistically different between the groups that received RAI and those that did not, in both the low- and intermediate-risk categories. In a subgroup analysis, within the intermediate-risk category, postoperative RAI was significantly correlated with decreased recurrence in two subgroups: patients over 55 years with pN1b disease (hazard ratio 0.043, 95% confidence interval 0.004-0.500, p = 0.012) and patients over 55 years with five or more metastatic lymph nodes (hazard ratio 0.060, 95% confidence interval 0.005-0.675, p = 0.023).

conclusionOur findings suggest that, while post-total thyroidectomy RAI does not substantially influence recurrence or survival rates in most low-risk and intermediate-risk PTC patients, it may be beneficial in specific subgroups, particularly patients over 55 with pN1b disease or those presenting with five or more metastatic lymph nodes.

Indexed as

Iodine RadioisotopesThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalRadiotherapy, AdjuvantRetrospective StudiesSurvival RateThyroidectomyTreatment OutcomeIodine RadioisotopesIntermediate-riskLow-riskPapillary thyroid carcinomaRadioactive iodineThyroidectomy

Identifiers

PMID39313708

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.