Evidence map›Paper›PMID 39313673›Full record

ArticleMolecular imaging and biology2024

Improved Quantification of MicroPET/CT Imaging Using CT-derived Scaling Factors.

Ayon Nandi, Masayoshi Nakano, James Robert Brašić, Zabecca S Brinson, Kelly Kitzmiller, Anil Mathur, Mona Mohamed, Joshua Roberts, Dean F Wong, Hiroto Kuwabara

Abstract read
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Article in Molecular imaging and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ayon NandiDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, JHOC Room 3243, 601 N. Caroline St, Baltimore, 21287, MD, USA.ORCID 0000-0002-1549-8900
Masayoshi NakanoClinical Science Division, R&D, Janssen Pharmaceutical K.K, Tokyo, Japan.
James Robert BrašićDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, JHOC Room 3243, 601 N. Caroline St, Baltimore, 21287, MD, USA.
Zabecca S BrinsonDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kelly KitzmillerRadiation Oncology, University of Maryland Medical Center, Baltimore, MD, USA.
Anil MathurDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, JHOC Room 3243, 601 N. Caroline St, Baltimore, 21287, MD, USA.
Mona MohamedRadiology, Ain Shams University, Cairo, Egypt.
Joshua RobertsDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dean F WongDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, JHOC Room 3243, 601 N. Caroline St, Baltimore, 21287, MD, USA.
Hiroto KuwabaraDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, JHOC Room 3243, 601 N. Caroline St, Baltimore, 21287, MD, USA. hkwaba1@jhmi.edu.

Funding

Combined mGluR5 PET and fMRI imaging of Sex Differences during Cocaine WithdrawalR01DA042094 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MCCAUL, MARY E, WAND, GARY S · 2017 to 2022
$3.5M
HOMOCYSTEINE, A CANDIDATE PERIPHERAL BIOMARKER FOR CEREBRAL mGluR5 ACTIVITY IN COMORBID ALCOHOL- AND TOBACCO USE DISORDERR01AA023483 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MCCAUL, MARY E, WONG, DEAN FOSTER · 2015 to 2019
$3.5M
NIAAA NIH HHS 1R01AA023483NIDA NIH HHS R01DA042094
6 · The paper itself

Abstract

purposeCombined micro-PET/CT scanners are widely employed to investigate models of brain disorders in rodents using PET-based coregistration. We examined if CT-based coregistration could improve estimates of brain dimensions and consequently estimates of nondisplaceable binding potential (BP PROCEDURES: PET and CT scans were acquired on 5 female and 5 male CD-1 mice with 3-[

resultsThe PET-based approaches showed various degrees of underestimations of scaling factors in the posterior-anterior-direction compared to PTCT, which resulted in negatively proportional overestimation of radioactivity in the cerebellum (reference region) up to 20%, and proportional, more prominent underestimation of BP

conclusionsThe results indicated that conventional PET-based coregistration approaches could yield biased estimates of BP

Indexed as

BrainPositron Emission Tomography Computed TomographyAnimalsFemaleImage Processing, Computer-AssistedMaleMice

Identifiers

PMID39313673

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.