Evidence map›Paper›PMID 39313655›Full record

ArticleProstate cancer and prostatic diseases2025

The appropriateness of PSMA PET/CT in newly diagnosed unfavorable intermediate-risk prostate cancer patients-towards a tumor volume-based risk stratification.

Marinus J Hagens, Wietske I Luining, Liselotte M S Boevé, Remco J J Knol, Ton A Roeleveld, Sandra Srbljin, Saskia Weltings, Jose C C Koppes, Daniela E Oprea-Lager, André N Vis and 2 more

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Article in Prostate cancer and prostatic diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marinus J Hagens *Department of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NCI-AVL), Amsterdam, The Netherlands. m.hagens@nki.nl.ORCID 0000-0001-6699-0201
Wietske I Luining *Department of Urology, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands.
Liselotte M S BoevéDepartment of Urology, OLVG, Amsterdam, The Netherlands.
Remco J J KnolDepartment of Nuclear Medicine, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands.
Ton A RoeleveldProstate Cancer Network Netherlands, Amsterdam, The Netherlands.
Sandra SrbljinDepartment of Nuclear Medicine, Zaans Medisch Centrum, Zaandam, The Netherlands.
Saskia WeltingsDepartment of Urology, Zaans Medisch Centrum, Zaandam, The Netherlands.
Jose C C KoppesDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands.
Daniela E Oprea-LagerDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands.
André N VisDepartment of Urology, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands.ORCID 0000-0003-3419-3368
Pim J van LeeuwenDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NCI-AVL), Amsterdam, The Netherlands.
Henk G van der PoelDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NCI-AVL), Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study reassesses the diagnostic value of PSMA PET/CT in unfavorable intermediate-risk prostate cancer (PCa) and validates the Prostate Cancer Network the Netherlands (PCNN) subclassification. SUBJECTS/

methodsMen subjected to PSMA PET/CT were analyzed, evaluating the incidence of metastatic disease and its correlation with PCNN subgroups.

resultsMetastatic disease was identified in 12.4% of patients. Higher PCNN subgroups correlated with increased metastatic potential; odds were significantly lower in low metastatic potential cases (OR: 0.19, 95% CI 0.06-0.62; p = 0.01).

conclusionsOur findings reaffirm PSMA PET/CT's diagnostic value in unfavorable intermediate-risk PCa and validate the PCNN subclassification, reducing scan burden by 48.1%.

Indexed as

Glutamate Carboxypeptidase IIPositron Emission Tomography Computed TomographyProstatic NeoplasmsAgedAged, 80 and overAntigens, SurfaceHumansMaleMiddle AgedPrognosisRisk AssessmentTumor BurdenAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase II

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.