ArticleScientific reports2024
Phytochemical, biological, and computational investigations of Ephedra alata Decne. growing in salinity conditions of Arabian Peninsula.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026Review
- Gallic Acid-Rich Ephedra alata: Integrated Phytochemical Profiling, Aromatase Docking, and Optimized Extraction via Box-Behnken Design.Chemistry & biodiversity · 2026Article
- Development and evaluation of multifunctional niosomal cream encapsulating tretinoin and integrated with hyaluronic acid and ceramides.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Impact of Salt Stress on Phytochemical Changes and Biological Activities of Quinoa Leaf Extracts In Vitro and In Silico.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Chemical composition and evaluation of the antibacterial and anti-migratory potentials of Anthemis maritima L. growing in North Africa.BMC complementary medicine and therapies · 2026Article
- Anticancer natural products from the Middle East and North Africa: biodiversity, mechanisms, and translational challenges.Frontiers in oncology · 2026Review
- Comparative study of the chemical profile, cytotoxic activity, and molecular docking of Serenoa repens extract and a pharmaceutical product.Scientific reports · 2025Article
- Machine learning optimization of environmental factors influencing biomass and nutritional composition in local algal species.Royal Society open science · 2025Article
- Potential Application ofDrug design, development and therapy · 2025Article
- The role of plant-based dietary compounds in gut microbiota modulation in inflammatory bowel disease.Frontiers in nutrition · 2025Review
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11 authors.
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Abstract
Ephedra alata Decne is a medicinal plant widely used in traditional medicine for the management of bronchial asthma and cancer. Phytochemical analysis and biological activities, including antioxidant and anticancer effects, were investigated in the current work as new findings for the plant E. alata, a species growing wildly in the marsh and saline environments of the central area of Saudi Arabia. The Ultra Pressure Liquid Chromatography coupled with Electron spray ionization-Quadropole-Time of flight (UPLC-ESI-Q-TOF) system was used for the phytochemical analysis of the plant constituents. In addition, Polyphenolic profiling including the total phenolic (TPC) and flavonoid (TFC) contents of the plant extracts were measured. Phenolic acids were found at the highest relative percentages among all the identified compounds and were measured at 66.07 mg GAE (Gallic acid equivalent). The UPLC analysis of the E. alata extract indicated the presence of chlorogenic acid, syringic acid, caffeic acid, vanillic acid, rosmarinic acid, umbelliferone, isorhoifolin, and apigenin at the highest relative percentages. Mineral analysis indicated that the microelement content of E. alata was relatively low, except for magnesium (Mg). In vitro antioxidant assays revealed the ability of the plant to scavenge DPPH free radicals, reduced molybdenum ions, and ferrous at levels of 14.63, 19.97, and 27.78 mg Trolox equivalents, respectively. The extract induced transition metal chelation at 31.36 mg EDTA equivalents. The extract induced cytotoxic effects against MDA-231 and A549 cell lines at IC
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