Evidence map›Paper›PMID 39313321›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain.

Li-Na Gong, Han-Wei Liu, Ke Lai, Zhen Zhang, Lin-Fei Mao, Zhen-Qi Liu, Ming-Xian Li, Xin-Lu Yin, Min Liang, Hai-Bo Shi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li-Na GongDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Han-Wei LiuDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Ke LaiDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Zhen ZhangDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Lin-Fei MaoDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Zhen-Qi LiuDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Ming-Xian LiDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Xin-Lu YinDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Min LiangDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Hai-Bo ShiDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China hbshi@sjtu.edu.cn luyang.wang@utoronto.ca skyin@sjtu.edu.cn.
Lu-Yang WangPrograms in Neurosciences & Mental Health, SickKids Research Institute and Department of Physiology, University of Toronto, Toronto, Ontario M5G 1X8, Canada hbshi@sjtu.edu.cn luyang.wang@utoronto.ca skyin@sjtu.edu.cn.ORCID 0000-0002-5399-944X
Shan-Kai YinDepartment of Otorhinolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China hbshi@sjtu.edu.cn luyang.wang@utoronto.ca skyin@sjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (

Indexed as

Animals, NewbornBilirubinGABAergic NeuronsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsAnimalsBrainFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPotassium ChannelsBilirubinHcn1 protein, mouseHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium Channelsauditory impairmentbilirubincochlear nucleus neuronGABAergic interneuronshyperpolarization-activated cyclic nucleotide-gated channelsneurotoxicity

Identifiers

PMID39313321
PMCPMC11551895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.