Evidence map›Paper›PMID 39313294›Full record

ArticleBMJ open ophthalmology2024

Cellular pattern and orbital fat involvement are possible risk factors for the failure of corticosteroids in patients with pure idiopathic orbital inflammation syndrome: lessons from the French prospective

Ambre La Rosa, Matthieu Groh, Antoine Martin, Stéphane Tran Ba, Nahla Cucherousset, Frédéric Mouriaux, Neila Sedira, Emmanuel Héron, Olivier Galatoire, David Saadoun and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ambre La RosaMédecine Interne, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (APHP), Bobigny, France.
Matthieu GrohMédecine Interne, Centre National de Référence des Syndromes Hyperéosinophiliques (CEREO), Hôpital Foch, Suresnes, France.
Antoine MartinAnatomopathologie, Hôpital Avicenne, APHP, Bobigny, France.
Stéphane Tran BaRadiologie, Hôpital Avicenne, AP-HP, Bobigny, France.
Nahla CucheroussetAnatomopathologie, Hôpital Avicenne, APHP, Bobigny, France.
Frédéric MouriauxOphtalmologie, Centre Hospitalier Universitaire de Rennes, Rennes, France.
Neila SediraMédecine Interne, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, Île-de-France, France.
Emmanuel HéronMédecine Interne, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, Île-de-France, France.
Olivier GalatoireChirurgie Oculoplastique, Fondation Adolphe de Rothschild, Paris, France.
David SaadounMédecine Interne, Hôpital Pitié Salpétrière, APHP, Paris, France.
Aïcha AbbasImmunologie Biologique, Hôpital Saint-Antoine, APHP, Paris, France.
Mboup BassirouUnité de Recherche Clinique, Hôpital Fernand Widal, AP-HP, Paris, France.
Eric VicautUnité de Recherche Clinique, Hôpital Fernand Widal, AP-HP, Paris, France.
Robin DhoteMédecine Interne, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (APHP), Bobigny, France.
Sebastien AbadMédecine Interne, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (APHP), Bobigny, France sebastien.abad@aphp.fr.ORCID 0000-0001-6401-7088
French Orbital Inflammation Study Group (GFEOI) and collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo better characterise the effects of corticosteroids on the course of pure idiopathic orbital inflammation syndrome (pIOIS).

methodsThis was a national, multicentre, prospective, non-interventional cohort study (

resultsOf the 17 patients with pIOIS included in the final analysis, two-thirds received corticosteroids only. DSDP (mg/kg-day) were significantly higher at the time of failure in eight patients (47%) than in nine (53%) remitting at M24 (0.16 vs 0.045; p: 0.03). Notably, patients with pIOIS with a cellular pattern or orbital fat involvement tended to receive higher daily corticosteroid doses in the event of failure than remission (0.16 vs 0.045 and 0.12 vs 0.042, respectively). During treatment, maximal DSDP was 0.52 in failed patients.

conclusionThe highest corticosteroid doses were insufficient to prevent failure in patients with pIOIS, particularly in those with a cellular pattern or orbital fat involvement. Large-scale interventional studies are now necessary to clarify prognostic factors and optimise corticosteroid management in patients with pIOIS.

Indexed as

GlucocorticoidsOrbital PseudotumorAdipose TissueAdultAgedFemaleFollow-Up StudiesFranceHumansMaleMiddle AgedOrbitPrednisoneProspective StudiesRisk FactorsTreatment FailureGlucocorticoidsPrednisoneImmunologyInflammationLacrimal glandOrbitTreatment Medical

Identifiers

PMID39313294
PMCPMC11418487

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