Evidence map›Paper›PMID 39313238›Full record

ArticleJournal of movement disorders2024

Monitoring Cognitive Functions During Deep Brain Stimulation Interventions by Real Time Neuropsychological Testing.

Ilaria Guarracino, Christian Lettieri, Massimo Mondani, Stanislao D'Auria, Giovanni Sciacca, Flavia Lavezzi, Miran Skrap, Serena D'Agostini, Gian Luigi Gigli, Mariarosaria Valente and 1 more

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In one paragraph

Article in Journal of movement disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilaria GuarracinoScientific Institute, IRCCS E. Medea, Dipartimento/Unità Operativa Pasian di Prato, Udine, Italy.
Christian LettieriClinical Neurology Unit, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Massimo MondaniNeurosurgery Unit, Department Head-Neck and Neurosciences, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Stanislao D'AuriaNeurosurgery Unit, Department Head-Neck and Neurosciences, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Giovanni SciaccaNeurosurgery Unit, Department Head-Neck and Neurosciences, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Flavia LavezziClinical Neurology Unit, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Miran SkrapNeurosurgery Unit, Department Head-Neck and Neurosciences, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Serena D'AgostiniNeuroradiology Unit, Department of Radiology, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Gian Luigi GigliClinical Neurology Unit, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Mariarosaria ValenteClinical Neurology Unit, Azienda Ospedaliero Universitaria Friuli Centrale, Udine, Italy.
Barbara TomasinoScientific Institute, IRCCS E. Medea, Dipartimento/Unità Operativa Pasian di Prato, Udine, Italy.

Funding

Ricerca Corrente
6 · The paper itself

Abstract

objectiveWe monitored cognition in 14 Parkinson's disease (PD) patients during deep brain stimulation (DBS) surgery when the electrode was positioned at the target subthalamic nucleus (STN) (i.e., the STN motor area).

methodsWe present the DBS-real-time neuropsychological testing (DBS-RTNT) protocol and our preliminary experience with it; we also compared the intraoperative patient performance with the baseline data.

resultsCompared with the baseline data, patients undergoing DBS-RTNT in the target area demonstrated a significantly decreased performance on some tasks belonging to the memory and executive function domains. Patients undergoing right hemisphere DBS-RTNT had significantly lower short-term memory and sequencing scores than did patients undergoing left hemisphere DBS-RTNT.

conclusionPD patient cognitive performance should be monitored during DBS surgery, as STN-DBS may induce changes. These preliminary data contribute to improving our understanding of the anatomo-functional topography of the STN during DBS surgery, which will enable the identification of the best site for producing positive motor effects without causing negative cognitive and/or emotional changes in individual patients in the future. In principle, medications (i.e., patients who underwent surgery in a levodopa-off state) could have influenced our results; therefore, future studies are needed to address the possible confounding effects of levodopa use.

Indexed as

Deep brain stimulationParkinson’s diseaseReal-time neuropsychological testingSubthalamic nucleusSurgery

Identifiers

PMID39313238
PMCPMC11540533

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.