Evidence map›Paper›PMID 39312720›Full record

ArticleThe Libyan journal of medicine2024

Interactions of electrophoretically silent hemoglobin Hekinan II [HBA1:c.84G>T] with various forms of α-thalassemias and other hemoglobinopathies: novel insights into the molecular and hematological characteristics and genetic origins.

Sitthichai Panyasai, Prasert Chantanaskulwong, Nopphadol Permsripong, Thippawal Mokmued

Abstract read
In one paragraph

Article in The Libyan journal of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Diagnostic Challenges of Hemoglobin (Hb) Hekinan with deletional αMediterranean journal of hematology and infectious diseases · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sitthichai PanyasaiDepartment of Medical Technology, School of Allied Health Sciences, University of Phayao, Phayao, Thailand.ORCID 0000-0002-7589-3849
Prasert ChantanaskulwongDepartment of Medical Technology, Phare Hospital, Phare, Thailand.
Nopphadol PermsripongDepartment of Medical Technology, Uttaradit Hospital, Uttaradit, Thailand.
Thippawal MokmuedDepartment of Medical Technology, Uttaradit Hospital, Uttaradit, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine the molecular basis, genotype - phenotype relationship, and genetic origin of Hemoglobin (Hb) Hekinan associated with several forms of α-thalassemia and other hemoglobinopathies for a better understanding of its diverse clinical phenotypes. Seventeen participants with suspected abnormal Hb were studied. Hb analysis was performed using high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE). Mutational and α-haplotypic and structural analyses were conducted, and the effects of mutations on globin-chain stability were determined. All participants harbored Hb Hekinan II (HBA1:c.84 G>T) co-inherited with another α-globin gene anomaly. Three novel genotypes, (αα

Indexed as

alpha-ThalassemiaElectrophoresis, CapillaryHemoglobinopathiesHemoglobins, AbnormalAdolescentAdultalpha-GlobinsChildChromatography, High Pressure LiquidFemaleGenetic Association StudiesGenotypeHaplotypesHumansMaleMiddle Agedalpha-GlobinsHemoglobins, Abnormalcapillary electrophoresisHemoglobin hekinan IIhigh-performance liquid chromatographyα-globin haplotypeα-hemoglobin variant

Identifiers

PMID39312720
PMCPMC11421131

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.