ArticleProceedings of the National Academy of Sciences of the United States of America2024
Cell-type-specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Acetylcholine enhances deviance detection in Hodgkin-Huxley neuronal networks.Cognitive neurodynamics · 2026Article
- Article
- Synaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injury.Science advances · 2026Article
- Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.iScience · 2026Article
- An Ultraresponsive Green Biosensor for Robust in Vivo Imaging of Synaptic Zinc Dynamics.ACS sensors · 2026Article
- ZIP-ZnT1 complexes mediate a local ZnCellular and molecular life sciences : CMLS · 2026Article
- Differential Myeloarchitecture of Subfields of the Mammalian Auditory Cortex: A Comparative Approach.Brain, behavior and evolution · 2026Review
- Article
- hpGRISZ: a high-performance fluorescent biosensor for in vivo imaging of synaptic zinc dynamics.bioRxiv : the preprint server for biology · 2025Article
- Primary auditory cortex is necessary for the acquisition and expression of categorical behavior.Current biology : CB · 2025Article
- The Astrocytic Zinc Transporter ZIP12 Is a Synaptic Protein That Contributes to Synaptic Zinc Levels in the Mouse Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cell-type-specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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5 authors.
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Abstract
Stimulus-specific adaptation is a hallmark of sensory processing in which a repeated stimulus results in diminished successive neuronal responses, but a deviant stimulus will still elicit robust responses from the same neurons. Recent work has established that synaptically released zinc is an endogenous mechanism that shapes neuronal responses to sounds in the auditory cortex. Here, to understand the contributions of synaptic zinc to deviance detection of specific neurons, we performed wide-field and 2-photon calcium imaging of multiple classes of cortical neurons. We find that intratelencephalic (IT) neurons in both layers 2/3 and 5 as well as corticocollicular neurons in layer 5 all demonstrate deviance detection; however, we find a specific enhancement of deviance detection in corticocollicular neurons that arises from ZnT3-dependent synaptic zinc in layer 2/3 IT neurons. Genetic deletion of ZnT3 from layer 2/3 IT neurons removes the enhancing effects of synaptic zinc on corticocollicular neuron deviance detection and results in poorer acuity of detecting deviant sounds by behaving mice.
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