Evidence map›Paper›PMID 39312468›Full record

ArticleeLife2024

Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair.

Jake Turley, Isaac V Chenchiah, Paul Martin, Tanniemola B Liverpool, Helen Weavers

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jake TurleySchool of Mathematics, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0001-8553-4367
Isaac V Chenchiah *School of Mathematics, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-8618-620X
Paul Martin *School of Biochemistry, University of Bristol, Bristol, United Kingdom.
Tanniemola B Liverpool *School of Mathematics, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0003-4376-5604
Helen Weavers *School of Biochemistry, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-5383-6085

Funding

Engineering and Physical Sciences Research Council EP/R014604/1Engineering and Physical Sciences Research Council EP/T031077/1Wellcome TrustWellcome Trust 10.35802/217169Wellcome Trust / Royal Society 208762/Z/17/Z
6 · The paper itself

Abstract

Cell division is fundamental to all healthy tissue growth, as well as being rate-limiting in the tissue repair response to wounding and during cancer progression. However, the role that cell divisions play in tissue growth is a collective one, requiring the integration of many individual cell division events. It is particularly difficult to accurately detect and quantify multiple features of large numbers of cell divisions (including their spatio-temporal synchronicity and orientation) over extended periods of time. It would thus be advantageous to perform such analyses in an automated fashion, which can naturally be enabled using deep learning. Hence, we develop a pipeline of deep learning models that accurately identify dividing cells in time-lapse movies of epithelial tissues in vivo. Our pipeline also determines their axis of division orientation, as well as their shape changes before and after division. This strategy enables us to analyse the dynamic profile of cell divisions within the

Indexed as

Cell DivisionDeep LearningDrosophila melanogasterMorphogenesisWings, AnimalAnimalsDrosophilaEpithelial CellsEpitheliumTime-Lapse ImagingWound Healingdeep learningdevelopmentdevelopmental biologyD. melanogasterepithelial cellsmodellingphysics of living systemswound healing

Identifiers

PMID39312468
PMCPMC11419669

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.