ArticleVeterinary medicine and science2024
Molecular Detection and Genetic Characterization of Avian Leukosis Virus From Field Outbreaks in Bangladesh.
Article in Veterinary medicine and science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- First complete genome of a fowlpox virus isolated in Bangladesh reveals Asian lineage and clade A1.Microbiology spectrum · 2026Article
- Acetylation-mediated regulation of ALV viral proteins: Implications for retroviral inhibition.PLoS pathogens · 2026Article
- Genome sequence of fowlpox virus from a field outbreak in Bangladesh.Microbiology resource announcements · 2025Article
- Genomic and pathological insights into the first identified genotype IIIb chicken anemia virus strain in Bangladesh.Microbiology spectrum · 2025Article
- Conventional diagnosis and metagenomic analysis of a novel co-infection case involving Escherichia coli and immunosuppressive conditions with petechial hepatitis of broilers in South Korea: a case report.BMC veterinary research · 2025Article
- Complete genome sequence of chicken anemia virus from a field outbreak in Bangladesh.Microbiology resource announcements · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Avian leukosis is a significant viral disease affecting chicken populations globally, including Bangladesh, resulting in high mortality and morbidity rates and causing substantial economic losses in the commercial poultry industry. This study aimed to detect avian leukosis virus (ALV) during recent outbreaks in Bangladesh, utilising a molecular-based approach. A total of 14 liver samples were collected from the suspected layer flocks in Bangladesh. The diagnosis of ALV infection in chickens was confirmed through necropsy, histopathological examinations, reverse transcription-polymerase chain reaction (RT-PCR), and sequence analysis. Gross observations revealed severe liver enlargement with scattered white nodules on the surface in the infected chickens. Histopathological observations showed the infiltration of huge mononuclear inflammatory cells in the periportal area of liver and microvesicular fatty degeneration and necrosis of some hepatocytes. RT-PCR results identified three samples positive for the env gene of ALV. Sequence analysis of the env genes demonstrated high homology among the identified strains (97%-98%) and with reference strains (92%-96%) at the nucleotide level. The phylogenetic tree revealed close relatedness of the three identified strains to reference strains from India, USA, and China. Mutational analysis indicated several mutations throughout the envelope glycoprotein of the identified strains. Protein structure analysis showed minor changes in the hydrophobic region of the envelope protein of the identified strains. In conclusion, this study, the first detailed investigation in Bangladesh, contributes to understanding ALV epidemiology, highlights genetic diversity, and emphasises the necessity for further investigations and the implementation of effective control measures in the affected regions.
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Registered trials
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