Evidence map›Paper›PMID 39312455›Full record

ReviewCancer journal (Sudbury, Mass.)

Immunoprevention Strategies for Colorectal Cancer in Lynch Syndrome Carriers.

Charles M Bowen, Krishna M Sinha, Eduardo Vilar

Abstract readReview
In one paragraph

Review in Cancer journal (Sudbury, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Targeted therapy in patients with genetic tumor syndromes.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Charles M BowenFrom the Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX.
Krishna M Sinha

Funding

Dietary HDAC Inhibitors in Colon Cancer PreventionR01CA122959 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DASHWOOD, RODERICK H · 2008 to 2023
$4.3M
Neoantigen Vaccination for Lynch Syndrome ImmunopreventionU01CA233056 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LIPKIN, STEVEN M, VILAR SANCHEZ, EDUARDO · 2018 to 2022
$3.8M
Cancer Immune-Interception for Lynch SyndromeR01CA257375 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIPKIN, STEVEN M, VILAR SANCHEZ, EDUARDO · 2021 to 2025
$3.3M
Cancer Immune-Interception in a Spontaneous Non-Human Primate Model of Lynch SyndromeR01CA260761 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI STANTON BRADLEY GRAY, Eduardo Vilar Sanchez · 2022 to 2026
$3.3M
Immunoepigenetic targeting of MHC regulators in FAPR01CA257559 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Roderick H Dashwood, Eduardo Vilar Sanchez · 2023 to 2026
$2.3M
NCI NIH HHS R01 CA122959NCI NIH HHS R01 CA257375NCI NIH HHS R01 CA257559NCI NIH HHS R01 CA260761NCI NIH HHS U01 CA233056
6 · The paper itself

Abstract

abstractThe immune revolution that swept the field of oncology in the mid-2010s with the advent of checkpoint inhibitors has led to a paradigm shift in approaches toward adapting new cancer prevention modalities. Cancer vaccines have emerged from this era with astounding potential as a durable intervention to prevent cancers especially for patients with hereditary susceptibilities such as Lynch syndrome carriers. This review covers new insights in the immunoprevention landscape for patients living with Lynch syndrome including highlights ranging from clinical trials exploring the use of chemoprevention agents to boost immune cellularity to investigative studies using novel vaccine approaches to induce long-term antitumor immunity.

Indexed as

Cancer VaccinesColorectal Neoplasms, Hereditary NonpolyposisChemopreventionColorectal NeoplasmsHumansImmune Checkpoint InhibitorsImmunotherapyCancer VaccinesImmune Checkpoint Inhibitors

Identifiers

PMID39312455
PMCPMC11424018

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.