Evidence map›Paper›PMID 39312415›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Bone Accrual Trajectories in Children and Adolescents With Perinatal HIV Infection.

Linda Anne DiMeglio, Wendy Yu, Heidi J Kalkwarf, Sean Brummel, Janet S Chen, Mitchell E Geffner, Elizabeth J McFarland, Ayesha Mirza, Kunjal Patel, Stephanie Shiau and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01418014 (Adolescent Master Protocol), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01418014 completednot on this map

Adolescent Master Protocol

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran2007 to 2021Enrolled678ConditionsHIV/AIDS
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Linda Anne DiMeglioDivision of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Riley Hospital for Children at IU Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8033-6078
Wendy YuCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-5967-2352
Heidi J KalkwarfDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0001-9030-8401
Sean BrummelCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-4116-404X
Janet S ChenDepartment of Pediatrics, Drexel University College of Medicine, Philadelphia, PA 19104, USA.ORCID 0009-0005-4934-5362
Mitchell E GeffnerThe Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA 90027, USA.ORCID 0000-0002-0384-3287
Elizabeth J McFarlandDepartment of Pediatric Infectious Diseases, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0003-0653-8955
Ayesha MirzaDivision of Pediatric Infectious Diseases, University of Florida, Jacksonville, FL 32209, USA.ORCID 0000-0002-2671-0903
Kunjal PatelDepartment of Epidemiology, Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-0002-681X
Stephanie ShiauDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.ORCID 0000-0003-2944-3406
Denise L JacobsonCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-5896-7148
Pediatric HIV/AIDS Cohort Study

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
The Adolescent Master Protocol (AMP) Up Series ProjectP01HD103133 · NICHD · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHADWICK, ELLEN GOULD, HERNANDEZ-DIAZ, SONIA · 2020 to 2024
$88.3M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentHarvard T.H. Chan School of Public Health HD052102Harvard T.H. Chan School of Public Health P01HD103133National Institute of Allergy and Infectious DiseasesNCI NIH HHSNHLBI NIH HHSNIAAA NIH HHSNICHD NIH HHS P01 HD103133NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104NIDA NIH HHSNIDCD NIH HHSNIDCR NIH HHSNIH HHSNIMH NIH HHSNINDS NIH HHSTulane University School of Medicine HD052104
6 · The paper itself

Abstract

contextLow bone mineral density (BMD) has been reported in children and adolescents living with perinatally acquired HIV (PHIV). Little is known about their bone accrual through puberty compared to an uninfected healthy cohort.

objectiveTo compare bone accrual in PHIV and healthy children.

designPHIV children aged 7 to 16 years had dual-energy X-ray absorptiometry at entry, at 2 years, and then at least 2 years later. Bone accrual was compared to healthy children from the Bone Mineral Density in Childhood Study (BMDCS).

settingUS academic clinical research centers. PATIENTS: 172 PHIV; 1321 BMDCS. ANALYSIS: We calculated height-adjusted whole-body and spine BMD and bone mineral content (BMC) Z-scores in PHIV using BMDCS reference curves. We fit piecewise weighted linear mixed effects models with change points at 11 and 15 years, adjusted for age, sex, race, height Z-score, and Tanner stage, to compare BMD and BMC Z-scores across actual age by cohort.

main outcome measureBMD/BMC Z-scores.

resultsHeight-adjusted whole-body BMD and BMC Z-scores in PHIV were lower across age compared to BMDCS children. Spine BMD Z-score across age was higher in PHIV after height adjustment. Whole-body and spine bone area tended to be lower in PHIV children. PHIV children had slower accrual in whole-body and spine bone area before 14 years. After 15 years, bone area accruals were similar, as were height-adjusted spine BMC Z-scores, across age.

conclusionPHIV children had persistent deficits in all measures except height-adjusted spine BMD and BMC Z-scores. Data are needed on PHIV children followed to adulthood.

Indexed as

Bone DensityBone DevelopmentHIV InfectionsAbsorptiometry, PhotonAdolescentChildCohort StudiesFemaleHumansInfectious Disease Transmission, VerticalLongitudinal StudiesMalebonechildrendensitygrowthHIVtrajectories

Identifiers

PMID39312415
PMCPMC12086409

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Registered trials

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