Evidence map›Paper›PMID 39312279›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Temporal trend and attributable risk factors of Alzheimer's disease and other dementias burden in China: Findings from the Global Burden of Disease Study 2021.

Kun Yang, Xuan Yang, Peng Yin, Maigeng Zhou, Yi Tang

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

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35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  8. The spleen-brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Kun YangNational Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China.
Xuan YangDepartment of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, P.R. China.
Peng YinNational Centre for Chronic and Noncommunicable Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, P.R. China.
Maigeng ZhouDepartment of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, P.R. China.
Yi TangDepartment of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, P.R. China.

Funding

National Key R&D Program of China 2022YFC3602600National Natural Science Foundation of China 81970996National Natural Science Foundation of China 82220108009STI2030-Major Projects 2021ZD0201801
6 · The paper itself

Abstract

introductionWe examined the burden of Alzheimer's disease and other dementias (ADOD) and attributable factors at the national and provincial levels in China.

methodsUsing the Global Burden of Diseases Study 2021, we estimated incidence, prevalence, mortality rate, disability-adjusted life years (DALYs), and the ratio of years lived with disability (YLD) to DALYs for ADOD in China. Estimated annual percentage changes (EAPCs) were used to quantify the temporal trends from 1990 to 2021.

resultsIn 2021, China experienced the highest ADOD burden among Group of 20 member nations. The EAPCs for age-standardized rates for incidence, age-standardized rates for prevalence, and age-standardized mortality rate were 0.41 (uncertainty intervals [UIs] 0.34-0.49); 0.44 (UI: 0.36-0.52); and -0.19 (UI: -0.23 to -0.15), respectively. Between 1990 and 2021, the number of people with ADOD increased by 322.18% and DALYs associated with ADOD increased by 272.71%; most of these increases were explained by population aging. DISCUSSION: Considering the aging Chinese population, targeted strategies to prevent dementia are urgently needed. HIGHLIGHTS: China experienced the highest dementia burden among Group of 20 member nations. High body mass index, high fasting plasma glucose, and smoking were major risk factors for Alzheimer's disease and other dementias (ADOD) burden. Since 1990, the incidence and prevalence of ADOD increased substantially in China. The mortality rate related to ADOD decreased consistently. Considering the aging Chinese population, targeted strategies are urgently needed.

Indexed as

Alzheimer DiseaseDementiaGlobal Burden of DiseaseAgedAged, 80 and overChinaDisability-Adjusted Life YearsFemaleHumansIncidenceMaleMiddle AgedPrevalenceRisk FactorsAlzheimer's disease and other dementiasdisability‐adjusted life yearsGlobal Burden of Diseases Studyincidencemortalityprevalence

Identifiers

PMID39312279
PMCPMC11567818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.