ArticleMethods in molecular biology (Clifton, N.J.)2025
SHAPE Probing to Screen Computationally Designed RNA.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Designing molecular RNA switches with Restricted Boltzmann machines.Nature communications · 2025Article
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3 authors.
Funding
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Abstract
RNA design is a major challenge for the future development of synthetic biology and RNA-based therapy. The development of efficient and accurate RNA design pipelines is based on trial and error strategies. The fast progression of such algorithms requires assaying the properties of many RNA sequences in a short time frame. High throughput RNA structure chemical probing technologies such as SHAPE-MaP allow for assaying RNA structure and interaction rapidly and at a very large scale. However, the promiscuity of the designed sequences that may differ only by one nucleotide requires special care. In addition, it necessitates the analysis and evaluation of many experimental results that may reveal to be very tedious. Here we propose an experimental and analytical workflow that eases the screening of thousands of designed RNA sequences at once. In particular, we have developed shapemap tools a customized software suite available at https://github.com/sargueil-citcom/shapemap-tools .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.