ArticleMacromolecular rapid communications2025
Zwitterionic Amino-Acid-Derived Polyacrylamides with a Betaine Twist - Synthesis and Characterization.
Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Bio-Inspired, Zwitterionic Copolymers with Amphiphilic Character.Macromolecular rapid communications · 2026Article
- Cyanoacetamidobetaine-A Zwitterionic Nitrile Derivative.ChemistryOpen · 2026Article
- Exploring the Multifunctional Roles of Betaine: Traditional Applications, Emerging Technologies, and Green Chemistry Innovations.Foods (Basel, Switzerland) · 2026Review
- An updated overview of alkaloids for the prevention and treatment of metabolic dysfunction-associated steatotic liver disease.Frontiers in pharmacology · 2026Review
- Review
- Zwitterionic Amino-Acid-Derived Polyacrylamides with a Betaine Twist - Synthesis and Characterization.Macromolecular rapid communications · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Amino-acid-derived polyzwitterions and polybetaines (PBs) are two promising alternatives to non-ionic polymers, for example, to increase tumor permeability. In this study, amino-acid-derived polyzwitterions are synthesized and a strategy to quarternize the amine in the side chain functional group is developed to combine the advantages of both types. The functional monomer is polymerized via reversible addition-fragmentation chain-transfer polymerization for which a kinetic study is performed. Further, the impact of the permanent positive charge on amino-acid-derived polyzwitterions is studied based on two zwitterionic polymers obtained via post-polymerization modification (PPM) of Poly(N-acryloxysuccinimide) to allow good comparison between methylated and non-methylated polymers. Circular dichroism shows that the stereocenter remains intact during PPM. pH titration and ζ-potential measurements show that the methylated polymer has a negative ζ-potential over the measured pH range and, therefore, the polymer remains zwitterionic over a broader pH range than its non-methylated equivalent. Both polymers are well tolerated by mammalian cells up to concentrations of 1 mg mL
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Registered trials
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